Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Merging of technology makes everyone a winner (page 1-2) Targeted Toxins: Safe, effective in vivo administration (page 5) IB4-Saporin, Neuroscience Antibodies (page 7) [fivecol_one]Page 1Page …
IB4, or the B4 lectin isoform from Bandeiraea simplicifolia (Griffonia simplicifolia), has played an important role in the delineation of the pathways of pain transmission. One of the two major groups of primary afferents that target the spinal cord dorsal horn neurons are labeled by IB4; the other group by TrkA and peptides such as …
Can you use targeted toxins in vivo? Yes, Molecular Neurosurgery is designed as a tool for in vivo use. How do you recommend administration of the targeted toxin? There are several ways to administer the toxins depending on the cells being targeted: Direct intraparenchymal pressure microinjection can be used to deliver the targeted toxin directly …
Loss of nerve: a molecular approach to better treatment of chronic pain. Friedrich MJ. JAMA 283(2):187-188, 2000. PMID: 10634324 The use of SP-SAP (Cat. #IT-07) as a promising new method for chronic pain relief is discussed in this review article. Chronic pain has classically been treated in ways that frequently have adverse effects on the …
Contributed by Dr. Ann Schreihofer, University of Virginia, contributes this issue’s article from the laboratories of ATS customers. Dr. Schreihofer summarizes her research with anti-DBH-SAP (Cat. #IT-03) to immunolesion specific rostral ventral medulla neurons that project to the spinal cord by injection of anti-DBH-SAP into the rat spinal cord. The toxin is taken up and …
Cover Article: Immunolesioning – From Spinal Cord to Brain Read More »