Vesicular GABA transporters (vGAT) mediate the accumulation of GABA into synaptic vesicles and its release from nerve terminals. This transporter is expressed in the nerve endings of GABAergic neurons throughout the CNS and has also been found in the pancreas and pituitary gland. During development, expression of the vGAT protein changes. Expression can also change in response to patterns of neuronal activity.
Anti-vGAT-SAP is a bonded toxin between a biotinylated rabbit polyclonal antibody and the secondary conjugate Streptavidin-ZAP containing the ribosome-inactivating protein, saporin. It specifically eliminates cells that express the vesicular GABA transporter.