Vesicular GABA transporters (vGAT) mediate the accumulation of GABA into synaptic vesicles and its release from nerve terminals. This transporter is expressed in the nerve endings of GABAergic neurons throughout the CNS and has also been found in the pancreas and pituitary gland. During development, expression of the vGAT protein changes. Expression can also change in response to patterns of neuronal activity.
Affinity-purified anti-vGAT was raised against the CÛÒterminal of the rat vesicular GABA transporter. The antigen sequence is identical among human, rat, mouse, pig and guinea pig. This antibody was affinity-purified using the C-terminal domain of vGAT. The antibody is routinely tested by flow cytometry.
Applications include immunoblotting and flow cytometry.
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