Hum-ZAP [IT-22, KIT-22]

a tool to “piggyback” onto YOUR antibody via affinity-purified goat anti-human IgG; targeting cells that recognize YOUR primary human monoclonal IgG antibody, eliminated via saporin

SKU: IT-22 Category: Antibody Type: affinity-purified | Host: Goat | Reactivity: Human | Conjugate: saporin | Usage: eliminates cells, screen antibodies |
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Hum-ZAP uses your primary human monoclonal IgG antibody to target and eliminate cells that recognize your primary antibody. This secondary conjugate uses the secondary antibody (affinity-purified goat anti-human IgG) to “piggyback” onto YOUR human primary antibody. Hum-ZAP can be utilized for screening human IgG antibodies for internalization and/or their suitability to make potent immunotoxins. When the in vitro results confirm the desired specificity, it is recommended that you order a custom conjugation of your antibody to saporin.

Hum-ZAP is a chemical conjugate of affinity-purified goat anti-human IgG and the ribosome-inactivating protein, saporin. It uses your human primary antibody to target and eliminate cells. This secondary conjugate is used to evaluate the potential of a primary antibody to internalize.

Hum-ZAP is available individually (Cat. #IT-22) or as a kit (Cat. #KIT-22) which includes Hum-ZAPSaporin (Cat. #PR-01)Goat IgG-SAP (Cat. #IT-19) and reagents for developing a cytotoxicity assay.