Alzheimer’s Disease Research
192-IgG-SAP (targets NGFR+ cells) Anti-DBH-SAP (targets dopamine beta hydroxylase)
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Saporin Publication highlighting 192-IgG-SAP and Anti-DBH-SAP
Summary: These results indicate a prominent role of NA-neurons vs. ACh ones in impairments of working memory, relevant for Alzheimer’s Disease. Usage: Bilateral icv injection of 192-IgG-SAP and/or Anti-DBH-SAP. G. Leanza and R. Zorec. Function 2023, 4(1) DOI: 10.1093/function/zqac060. We would be pleased to send you our 2023 ATS calendar. Click here to provide us your
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ZAP Antibody Internalization Kit Introduction
ZAP Antibody Internalization Kit Also available in French | German | Japanese | Korean | Mandarin | Italian | Portuguese | Spanish ZAP Antibody Internalization Kit Explainer Whiteboard Browse kit options and order your kit. keywords: research, drug development, bind to cell types, ZAP Antibody Internalization Kit, screen antibodies, binding, internalization, cytotoxicity assay, specific, secondary, saporin, primary, cell surface marker, internalized
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A Brief History of Saporin and its Contributions to Neuroscience
ABSTRACT When investigating the origins of targeted toxins (a drug, therapy, or scientific tool directed to unique extracellular target), an appropriate place to begin is with the Nobel Prize-winning work of Paul Ehrlich and his concept of the “magic bullet.” Over 100 years later, the use of targeted toxins to perform molecular neurosurgery has become
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Targeting Trends 2021 Review
Read the complete 2021 Review including recent scientific references. Targeted Ablation with IB4-SAP: Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis Top 20 Targeting Tools
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Top 20 Targeting Tools of 2021
Top Five Targeted Toxins #1. CTB-SAP (Cat. #IT-14) – targets cells expressing GM1 receptor #2 Mac-1-SAP (Cat. #IT-06) – targets cells expressing Mac-1 (CD11b ) receptor #3 Anti-CD103-SAP (Cat. #IT-50) – targets cells expressing CD103 #4. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase #5. mu p75-SAP (Cat. #IT-16) – targets cells expressing mouse
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Targeted Ablation with IB4-SAP
Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis Kayla L. Nguyen1, Sydney R. Lamerand1, Ronit P. Deshpande1, Bradley K. Taylor1,2 1Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA2Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA
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Top 20 Targeting Tools of 2020
Top Five Targeted Toxins #1. CTB-SAP (Cat. #IT-14) – targets cells expressing GM1 receptor #2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase #3. IB4-SAP (Cat. #IT-10) – targets cells expressing alpha-D-galactopyranoside residues #4. mu p75-SAP (Cat. #IT-16) – targets cells expressing mouse p75NTR #5. ME20.4-SAP (Cat. #IT-15) – targets cells expressing multiple mammalian
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