Search Results for “neuroscience” – Page 10

Tools and Services to Advance your Research and Drug Development

TOOLS FOR SELECTIVELY ALTERING CELLS BASED ON CELL-SURFACE MARKERS You’re still publishing and we’re still open to meet your targeting needs. You can place your orders online or contact us. Stay safe and healthy!Denise Higginswww.ATSbio.com SERVICES FOR SELECTIVELY ALTERING AND ASSAYING CELLS Restricted access can slow or halt your research and drug development activities. We […]

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Targeting Tools: Investigating the Itch Pathway

News Tools / Kristen Hartman

Bombesin-SAP (Cat. #IT-40) Bombesin is a 14-amino-acid peptide found in frog-skin. The human equivalent, gastrin releasing peptide (GRP) has been detected in itch pathways and plays a role in eating behaviors. GRP regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.

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Cover Article: Impairments in gait, posture and complex movement control in rats modeling the multi-system, cholinergic-dopaminergic losses in Parkinson’s Disease

News Article / Kristen Hartman

by Aaron Kucinski (Collaborators at University Michigan, Ann Arbor: K. Phillips, R. Albin, M. Sarter) In addition to the primary disease-defining symptoms that result from extensive loss of nigrostriatal dopaminergic neurons, approximately half of patients with Parkinson’s Disease (PD) suffer from postural instability, impairments in gait control and a propensity for falls. These symptoms have

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Targeting Tools: Anti-ChAT-SAP

News Tools / Kristen Hartman

Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both peripheral and central nervous systems. Evidence shows that ChAT exists in two forms inside cholinergic nerve terminals, a soluble hydrophilic form and the membrane-associated amphiphilic form.[1-2]

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IB4-SAP to study mechanical hyperalgesia

Targeting Topics / Kristen Hartman

To determine which subtype of nociceptor, peptidergic or non-peptidergic, is involved in the mechanical hyperalgesia induced by LMWH (low molecular weight hyaluronan), rats were pretreated with neurotoxins previously shown to selectively deplete these two types of sensory neurons: Isolectin B4 (IB4)-saporin (SAP), which acts on IB4-positive, non-peptidergic neurons (Cat. #IT-10 IB4-SAP), and substance P-saporin (Cat.

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Targeting Tools: Targeting the Dopamine Transporter

News Tools / Kristen Hartman

Advanced Targeting Systems announces the availability of two monoclonal antibodies to the dopamine transporter (DAT). These antibodies have become a standard for work on DAT and have already played a prominent role in the characterization of the dopamine transporter. The two antibodies are rat monoclonals, so they can be excellent for multiple staining protocols. Anti-DAT-NT, Cat.

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Target Microglia for Elimination

Targeting Topics / Kristen Hartman

In a study produced by Ferrini et al. indicates that morphine-induced hyperalgesia, as neuropathic pain, is a pathological alteration of pain sensitivity whose expression is gated by spinal microglia. Targeting at any level, this microglia-to-neuron cascade is a valuable strategy to improve the use of morphine in chronic pain. Figure at right: Microglia depletion in

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Apoptosis or Necrosis?

Kristen Hartman

Q: Do targeted toxin-treated cells die by apoptosis? A: There are, allegedly, two ways for cells to die: by apoptosis or necrosis. According to Fiorenzo Stirpe (the discoverer of saporin), saporin-intoxicated cells die both ways, some by one, others by the other. There is good literature that states that cells die by apoptosis. Saporin and

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Targeting Article: Targeted Toxins, Optogenetics, and the BRAIN Initiative

News Article / Kristen Hartman

Contributed by Brian J. Russell The newly invigorated BRAIN initiative (Brain Research through Advancing Innovative Neurotechnologies, also known as the Brain Activity Map Project) has placed a premium on understanding the role of each neuron within the human brain. This effort has been our focus for some time via our Targeted Toxin technology. From the

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Search Results for: neuroscience