- Home
- Knowledge Base
- References
References
Mixed vehicle emissions induces angiotensin ii and cerebral microvascular angiotensin receptor expression in C57Bl/6 mice and promotes alterations in integrity in a blood-brain barrier coculture model.
Suwannasual U, Lucero J, Davis G, McDonald JD, Lund AK (2019) Mixed vehicle emissions induces angiotensin ii and cerebral microvascular angiotensin receptor expression in C57Bl/6 mice and promotes alterations in integrity in a blood-brain barrier coculture model. Toxicol Sci 170(2):525-535. doi: 10.1093/toxsci/kfz121 PMID: 31132127
Objective: To investigate the hypothesis that inhalation exposure to a mixture of gasoline and diesel vehicle engine emissions (MVE) results in altered central nervous system microvascular integrity mediated by Ang II-AT1 signaling.
Summary: Inhalation exposure to traffic-generated pollutants results in altered BBB integrity, mediated through Ang II-AT1 signaling and inflammation, which is exacerbated by a high-fat diet.
Usage: Antibody was used in immunofluorescent staining of cerebral tissue. Brain sections (10 mm) were prepared for AT1 receptor (1:1000).
Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)
RGS14414 treatment induces memory enhancement and rescues episodic memory deficits.
Masmudi‐Martin M, Navarro‐Lobato I, López‐Aranda MF, Delgado G, Martín‐Montañez E, Quiros‐Ortega ME, Carretero‐Rey M, Narváez L, Garcia‐Garrido MF, Posadas S, López‐Téllez JF, Blanco E, Jiménez‐Recuerda I, Granados‐Durán P, Paez‐Rueda J, López JC and Khan ZU (2019) RGS14414 treatment induces memory enhancement and rescues episodic memory deficits. FASEB J 33:11804-11820. doi: 10.1096/fj.201900429RR
Objective: To investigate the effect of the promotion of neuronal arborization through the expression of the regulator of G-protein signaling 14 of 414 amino acids (RGS14414).
Summary: In addition to showing the potential of RGS14414 for rescuing memory deficits, our results suggest that a boost in circuit activity could facilitate memory enhancement and the reversal of memory deficits.
Usage: 0.9 mg in 1 ml was injected into the PRh.
Related Products: OX7-SAP (Cat. IT-02)
The role of the brain in the regulation of peripheral noradrenaline-producing organs in rats during morphogenesis.
Murtazina AR, Nikishina YO, Dil’mukhametova LK, Sapronova AY, Ugrumov MV (2019) The role of the brain in the regulation of peripheral noradrenaline-producing organs in rats during morphogenesis. Dokl Biochem Biophys 486(1):243-246. doi: 10.1134/S1607672919030207
Related Products: Anti-DBH-SAP (Cat. #IT-03)
A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours.
Fu R, Han C-F, Ni T, Di L, Liu L-J, Lv W-C, Bi Y-R, Jiang N, He Y, Li H-M, Wang S, Xie H, Chen B-A, Wang X-S, Weiss SJ, Lu T, Guo Q-L, Wu Z-Q (2019) A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours. Nat Commun 10(1):3210. doi: 10.1038/s41467-019-11278-7 PMID: 31324807
Usage: immunohistochemistry (1:100)
Related Products: Fibroblast Growth Factor Rabbit Polyclonal, mammalian (Cat. #AB-07)
Spinal neuropeptide Y1 receptor-expressing neurons form an essential excitatory pathway for mechanical itch.
Acton D, Ren X, DiCostanzo S, Dalet A, Bourane S, Bertocchi I, Eva C, Goulding M (2019) Spinal neuropeptide Y1 receptor-expressing neurons form an essential excitatory pathway for mechanical itch. Cell Reports 28(3):625-639.e6 . doi: 10.1016/j.celrep.2019.06.033
Objective: To determine the central pathway for mechanical itch.
Summary: NPY-Y1 signaling regulates the transmission of innocuous tactile information by establishing biologically relevant thresholds for touch discrimination and mechanical itch reflexes. Neither the evoked nor spontaneous scratching seen following activation of Y1Cre neurons was affected by ablation of the GRPR+ neurons. NK1R+ neuron ablation failed to modulate mechanically evoked itch.
Usage: P28 mice were given a single intrathecal (i.t.) injection of either Bombesin-SAP (400 ng in 5 mL 0.9% sterile saline) to ablate GRPR+ cells or SSP-SAP to ablate NK1r+ neurons (100 ng in 5 mL 0.9% sterile saline). Littermate controls received Blank-SAP (equal mass in 5 mL 0.9% sterile saline).
Related Products: Bombesin-SAP (Cat. #IT-40), SSP-SAP (Cat. #IT-11), Blank-SAP (Cat. #IT-21)
∆Np63 executes an oncogenic program through the regulation of a common landscape of super-enhancer associated genes in non-small cell lung cancer
Wu SJ, Coarfa C, Abbas H, Checker R, Dhar S, Rajapakshe K, Lee MG, Flores ER (2019) ∆Np63 executes an oncogenic program through the regulation of a common landscape of super-enhancer associated genes in non-small cell lung cancer. Cell Reports 3420369. doi: 10.2139/ssrn.3420369
Objective: To investigate how ΔNp63 serves to maintain lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) through the regulation and maintenance of lung stem cells that are necessary for lung adenocarcinoma and squamous cell initiation and progression.
Summary: ∆Np63 maintains lung ADC and SCC by keeping lung stem cells in quiescence. ChIP-seq analysis of lung basal cells and alveolar type 2 (AT2) cells lacking ∆Np63 revealed a robust loss of activating histone marks at super enhancers of cell identity genes defining a unifying oncogenic role for ∆Np63 in non-small cell lung cancer.
Usage: staining
Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)
Interleukin-1 reduces food intake and body weight in rat by acting in the arcuate hypothalamus
Chaskiel L, Bristow AD, Bluthé RM, Dantzer R, Blomqvist A, Konsman JP (2019) Interleukin-1 reduces food intake and body weight in rat by acting in the arcuate hypothalamus. Brain Behav Immun 81:560-573. doi: 10.1016/j.bbi.2019.07.017
Summary: The authors tested the hypothesis that IL-1R1 expressing cells in the ARH mediate IL-1β and/or LPS-induced hypophagia in the rat.
Related Products: Custom Conjugates, Saporin (Cat. #PR-01)
Light responses of melanopsin-expressing ganglion cells in the foetal mammalian retina
Verweij J, Chaney SY, Bredl D, Vemaraju S, König GM, Kostenis E, Lang RA, Copenhagen DR (2019) Light responses of melanopsin-expressing ganglion cells in the foetal mammalian retina. bioRxiv 675702. doi: 10.1101/675702
Related Products: Melanopsin Rabbit Polyclonal, affinity-purified (Cat. #AB-N39)
Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats.
Ikeda K, Onimaru H, Inada H, Tien Lin S, Arata S, Osumi N (2019) Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats. Brain Res Bull 152:107-116. doi: 10.1016/j.brainresbull.2019.07.007 PMID: 31301380
Objective: To determine whether the respiratory center in the medulla functions normally in Pax6 mutant rats.
Summary: The Pax6 gene is involved in the functional development of the medullary respiratory center.
Usage: Anti-NK1r was used in immunofluorescence (1:800).
Related Products: NK-1 Receptor Rabbit Polyclonal, affinity-purified (Cat. #AB-N33AP)
Neuroprotective effects of exercise on the morphology of somatic motoneurons following the death of neighboring motoneurons.
Chew C, Sengelaub DR (2019) Neuroprotective effects of exercise on the morphology of somatic motoneurons following the death of neighboring motoneurons. Neurorehabil Neural Repair 33(8):656-667. doi: 10.1177/1545968319860485
Objective: To explore whether exercise shows the same neuroprotective effect on induced dendritic atrophy as that seen with androgen treatment.
Summary: Exercise following neural injury exerts a protective effect on motoneuron dendrites comparable to that seen with exogenous androgen treatment.
Usage: Motoneurons innervating the left vastus medialis muscle were selectively killed by intramuscular injection of CTB-SAP (2 μL, 0.1%). Saporin injection reduced the weight of the vastus medialis muscle; exercise had no effect on muscle weight.
Related Products: CTB-SAP (Cat. #IT-14)