Intervening B-type natriuretic peptide signaling for controlling chronic itch.

Meng J, Chen W, Wang J (2020) Intervening B-type natriuretic peptide signaling for controlling chronic itch. Brit J Pharmacol 177(5):1025-1040. doi: 10.1111/bph.14952

Objective: Review of recent findings used to examine the role of B-type natriuretic peptide (BNP) in itch transduction and the modulation of other pururitic proteins.

Summary: Mice treated with Nppb-SAP ablated 70% of the BNP receptor-positive neurons in the spinal cord.

Related Products: Nppb-SAP (Cat. #IT-69)

See Also:

• Mishra SK et al. The cells and circuitry for itch responses in mice. Science 340(6135):968-971, 2013.
• Pitake S et al. Atopic Dermatitis Linked Cytokine Interleukin-31 Induced Itch Mediated via a Neuropeptide Natriuretic Polypeptide B. Acta Derm Venereol 98:795-796, 2018.