- Home
- Knowledge Base
- References
References
Further analysis of the effects of immunotoxic lesions of the basal nucleus of Meynert reveals substantial impairment on visual discrimination learning in monkeys.
Ridley RM, Baker HF, Leow-Dyke A, Cummings RM (2005) Further analysis of the effects of immunotoxic lesions of the basal nucleus of Meynert reveals substantial impairment on visual discrimination learning in monkeys. Brain Res Bull 65(5):433-442. doi: 10.1016/j.brainresbull.2005.02.025
Summary: Several studies in marmoset monkeys indicate that cholinergic projections from the NBM to specific portions of the neocortex are necessary for visual discrimination learning. By combining analysis of studies using a total of 1.4 µg of ME20.4-SAP (Cat. #IT-15) into various areas of the brain, the authors show that degeneration of cholinergic projections contributes to the loss of functions dependent on the neocortex.
Related Products: ME20.4-SAP (Cat. #IT-15)
Telomere dysfunction in aging and cancer.
Gilley D, Tanaka H, Herbert BS (2005) Telomere dysfunction in aging and cancer. Int J Biochem Cell Biol 37(5):1000-1013. doi: 10.1016/j.biocel.2004.09.003 PMID: 15743674
Related Products: TRF1 Mouse Monoclonal (Cat. #AB-37)
Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons.
Lopez-Coviella I, Follettie MT, Mellott TJ, Kovacheva VP, Slack BE, Diesl V, Berse B, Thies RS, Blusztajn JK (2005) Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A 102(19):6984-6989. doi: 10.1073/pnas.0502097102 PMID: 15870197
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01), NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)
Selective cholinergic immunolesioning affects synaptic plasticity in developing visual cortex.
Kuczewski N, Aztiria E, Leanza G, Domenici L (2005) Selective cholinergic immunolesioning affects synaptic plasticity in developing visual cortex. Eur J Neurosci 21(7):1807-1814. doi: 10.1111/j.1460-9568.2005.04014.x
Summary: In this study the authors examined the role of subcortical cholinergic inputs in the regulation of plastic events in the visual cortex during early postnatal development. Four-day-old mouse pups were treated with a total of 0.4 µg of 192-Saporin (Cat. #IT-01), using bilateral injections. Analysis of muscarinic receptor mRNA, long-term potentiation of cortex slices, and theta burst stimulation indicated that synaptic transmission and plasticity of the developing visual cortex depends on cholinergic input.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Removal of cholinergic input to perirhinal cortex disrupts object recognition but not spatial working memory in the rat.
Winters BD, Bussey TJ (2005) Removal of cholinergic input to perirhinal cortex disrupts object recognition but not spatial working memory in the rat. Eur J Neurosci 21(8):2263-2270. doi: 10.1111/j.1460-9568.2005.04055.x
Summary: The perirhinal cortex of the temporal lobe is crucial to object recognition memory. The authors examined the role of cholinergic input from the basal forebrain in this process. Rats were injected bilaterally with 0.2 µl of 0.02 µg/µl 192-Saporin (Cat. #IT-01) into 3 sites of the perirhinal cortex, and tested in object recognition and spatial working memory tasks. Spatial working memory remained intact, but object recognition was impaired, indicating a specific function for cholinergic input to the perirhinal cortex.
Related Products: 192-IgG-SAP (Cat. #IT-01)
B fragment of cholera toxin conjugated to saporin
Ohara PT, Kelley K, Jasmin L (2005) B fragment of cholera toxin conjugated to saporin . (eds. Ronald GW, Douglas AL). Molecular Neruosurgery With Targeted Toxins 293-306. Humana. doi: 10.1007/978-1-59259-896-0_13
Summary: CTB-Saporin is a lesioning tool used to target GM1 ganglioside residues, which are highly expressed within certain nervous cell tissue. It distinguishes itself from other common saporin conjugates as it is most used not to lesion neurons but instead mylelin producing oligodendrocytes. CTB-SAP can be used to target these cells in order to study demyelination and remyelination in the spinal cord.
Related Products: CTB-SAP (Cat. #IT-14)
Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release.
Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL (2005) Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. J Neurosci 25(14):3651-3660. doi: 10.1523/JNEUROSCI.0252-05.2005 PMID: 15814796
Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)
Featured Article: Noradrenergic inputs to the medial amygdala originate in the A1 and A2 cells groups and release norepinephrine after mating stimulation sufficient to induce pseudopregnancy
Northrop LE, Cameron N, Erskine M (2005) Featured Article: Noradrenergic inputs to the medial amygdala originate in the A1 and A2 cells groups and release norepinephrine after mating stimulation sufficient to induce pseudopregnancy. Targeting Trends 6(2)
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Hereditary ferritinopathy: a novel mutation, its cellular pathology, and pathogenetic insights
Mancuso M, Davidzon G, Kurlan RM, Tawil R, Bonilla E, Di Mauro S, Powers JM (2005) Hereditary ferritinopathy: a novel mutation, its cellular pathology, and pathogenetic insights. J Neuropathol Exp Neurol 64(4):280-294. doi: 10.1093/jnen/64.4.280 PMID: 15835264
Related Products: Malondialdehyde Rabbit Polyclonal, Conjugated (Cat. #AB-T090)
Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine.
Mothet JP, Pollegioni L, Ouanounou G, Martineau M, Fossier P, Baux G (2005) Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine. Proc Natl Acad Sci U S A 102(15):5606-5611. doi: 10.1073/pnas.0408483102 PMID: 15800046
Related Products: D-Serine Rabbit Polyclonal, Conjugated (Cat. #AB-T048)