Winters BD, Bussey TJ (2005) Removal of cholinergic input to perirhinal cortex disrupts object recognition but not spatial working memory in the rat. Eur J Neurosci 21(8):2263-2270. doi: 10.1111/j.1460-9568.2005.04055.x
Summary: The perirhinal cortex of the temporal lobe is crucial to object recognition memory. The authors examined the role of cholinergic input from the basal forebrain in this process. Rats were injected bilaterally with 0.2 µl of 0.02 µg/µl 192-Saporin (Cat. #IT-01) into 3 sites of the perirhinal cortex, and tested in object recognition and spatial working memory tasks. Spatial working memory remained intact, but object recognition was impaired, indicating a specific function for cholinergic input to the perirhinal cortex.
Related Products: 192-IgG-SAP (Cat. #IT-01)