References

Abe T, Ohshita N, Sugiyo S, Moritani M, Kobayashi M, Takemura M (2005) Elimination of neurokinin-1 receptor neurons in caudal nucleus reverses the effects of systemic bicuculline on c-Fos expression in rat trigeminal sensory nucleus: I. High intensity electrical stimulation of the trigeminal ganglion. Neuroscience 133(3):739-747. doi: 10.1016/j.neuroscience.2005.03.021

Summary: The authors investigated the role of NK-1r + neurons in lamina 1 of the trigeminal caudal nucleus (Vc) for ora-facial nociception. After a 5 µl injection of 5 µM SP-SAP (Cat. #IT-07) into the cisterna magna, c-fos expression in the Vc was evaluated. SP-SAP treatment, along with use of bicuculline, a GABAA receptor antagonist, showed that NK-1r+ neurons in laminae I and III of the Vc are involved in nociceptive processing in the trigeminal sensory nucleus.

Related Products: SP-SAP (Cat. #IT-07)

Pagliardini S, Ren J, Wevrick R, Greer JJ (2005) Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin. Am J Pathol 167(1):175-191. doi: 10.1016/S0002-9440(10)62964-1 PMID: 15972963

Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)

Zhang RX, Wang L, Liu B, Qiao JT, Ren K, Berman BM, Lao L (2005) Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation. Brain Res 1048(1-2):235-240. doi: 10.1016/j.brainres.2005.05.008

Summary: Electroacupuncture has been shown to significantly reduce inflammatory hyperalgesia. To examine whether this effect is modulated by spinal mu opioid receptors, the authors injected 400 ng of dermorphin-SAP (Cat. #IT-12) into the subarachnoid space at the level of the lumbar spinal cord of rats. The anti-hyperalgesic effect of electroacupuncture was blocked by dermorphin-SAP administration, indicating that mu opioid receptor-containing neurons are involved in this pathway.

Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12)

Smith HR, Pang KC (2005) Orexin-saporin lesions of the medial septum impair spatial memory. Neuroscience 132(2):261-271. doi: 10.1016/j.neuroscience.2004.12.037

Summary: The medial septum and diagonal band of Broca (MSDB) have been shown to be important for spatial learning and memory. The authors investigated the role orexin-containing neurons from the hypothalamus play in these processes. Rats were treated with three injections of 40-120 ng of orexin-SAP (Cat. #IT-20) into the MSDB. Performance in spatial working and spatial reference memory tasks indicate that orexin innvervation of the MSDB may modulate spatial memory through both GABAergic and cholinergic septohippocampal neurons.

Related Products: Orexin-B-SAP (Cat. #IT-20)

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Paban V, Jaffard M, Chambon C, Malafosse M, Alescio-Lautier B (2005) Time course of behavioral changes following basal forebrain cholinergic damage in rats: Environmental enrichment as a therapeutic intervention. Neuroscience 132(1):13-32. doi: 10.1016/j.neuroscience.2004.11.024

Summary: In this study the authors examined the effects of 192-Saporin (Cat. #IT-01) administration to the medial septum (37.5 ng/side) and nucleus basalis magnocellularis (75 ng/side) of rats. The results suggest that behavioral deficits immediately after lesioning are due to cholinergic depletion, while deficits later in life may be connected to a gradual degeneration process. Environmental enrichment had a significant positive effect on lesioned rats, indicating a level of cognitive plasticity.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Mohapel P, Leanza G, Kokaia M, Lindvall O (2005) Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Neurobiol Aging 26:939-946. doi: 10.1016/j.neurobiolaging.2004.07.015

Summary: New hippocampal neurons that are thought to be involved in memory formation are generated in the dentate gyrus (DG) throughout adulthood. In this study, rats were injected at various sites with 192-Saporin (Cat. #IT-01). The authors found that acetylcholine levels, which are reduced upon administration of 192-Saporin, are linked to proliferation and/or short-term survival of DG neurons, rather than long-term survival or differentiation. Cognitive defects that could be linked to the reduced number of new neurons were also observed.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Hartonian I, de Lacalle S (2005) Compensatory changes in cortical cholinergic innervation in the rat following an immunotoxic lesion. Restor Neurol Neurosci 23(2):87-96.

Summary: The ability of damaged axons to grow and functionally reinnervate damaged areas of the brain is well documented. Here the authors study this process in the context of rats lesioned with 192-Saporin (Cat. #IT-01). 10.5 ng of the immunotoxin was injected into the right horizontal diagonal band of Broca, and animals were examined from 2 to 24 weeks later. Although the functionality of the neuronal ingrowth was not examined, surviving neurons did extend their terminals into the denervated area.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Scattoni ML, Puopolo M, Calamandrei G, Ricceri L (2005) Basal forebrain cholinergic lesions in 7-day-old rats alter ultrasound vocalisations and homing behaviour. Behav Brain Res 161(1):169-172. doi: 10.1016/j.bbr.2005.01.011

Summary: In this study the authors examined the effects of cholinergic depletion of the basal forebrain on the establishment and maintenance of mother-pup interaction in rats. Post-natal day 7 pups were lesioned with bilateral intracerebroventricular injections of 192-Saporin (0.42 µg, Cat. #IT-01). Treated animals displayed a reduced number of ultrasonic vocalizations, as well as apparent increased difficulty in identifying the nest “boundary.” The evidence shows that early damage to basal forebrain cholinergic nuclei can influence behavior as early as the second-postnatal week.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Guillemin GJ, Brew BJ, Noonan CE, Takikawa O, Cullen KM (2005) Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer’s disease hippocampus. Neuropathol Appl Neurobiol 31(4):395-404. doi: 10.1111/j.1365-2990.2005.00655.x PMID: 16008823

Related Products: Quinolinic Acid Rabbit Polyclonal, Conjugated (Cat. #AB-T095)

Gu G, Kondo I, Hua XY, Yaksh TL (2005) Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence. J Pharmacol Exp Ther 314(3):1362-1369. doi: 10.1124/jpet.105.087718 PMID: 15908510

Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)