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Selective and efficient inhibition of the alternative pathway of complement by a mAb that recognizes C3b/iC3b
DiLillo DJ, Pawluczkowycz AW, Peng W, Kennedy AD, Beum PV, Lindorfer MA, Taylor RP (2006) Selective and efficient inhibition of the alternative pathway of complement by a mAb that recognizes C3b/iC3b. Mol Immunol 43(7):1010-1019. doi: 10.1016/j.molimm.2005.05.003 PMID: 15961157
Related Products: Antibody to Complement C3 (1H8) (Cat. #AB-V83)
Safety evaluation of Intrathecal Substance P-Saporin, a targeted neurotoxin, in dogs.
Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL (2006) Safety evaluation of Intrathecal Substance P-Saporin, a targeted neurotoxin, in dogs. Toxicol Sci 91(1):286-298. doi: 10.1093/toxsci/kfj143
Summary: SP-SAP (Cat. #IT-07) has been shown to reverse neuropathic pain behavior in rodents and prevent the formation of hyperalgesia. A safety study was done in beagles to further the use of this molecule as a human therapeutic. Animals received doses from 1.5-150 µg of SP-SAP as bolus intrathecal lumbar injections. Doses of 15 µg and above displayed significant loss of NK1r-expressing cells in lumbar Laminae II and I, but no adverse toxicity was observed at any dose.
Related Products: SP-SAP (Cat. #IT-07)
Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model.
Foehr ED, Lorente G, Kuo J, Ram R, Nikolich K, Urfer R (2006) Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. Cancer Res 66(4):2271-2278. doi: 10.1158/0008-5472.CAN-05-1221
Summary: The receptor protein tyrosine phosphatase ß (RPTPß) is overexpressed in astrocytomas, and is a potential target for tumor therapy. After testing antibodies against an extracellular domain of RPTPß in vitro with Mab-ZAP (Cat. #IT-04), two custom conjugates, 7E4B11-SAP and 7A9B5-SAP, were created by Advanced Targeting Systems. The authors tested the custom conjugates, using anti-DAT-SAP (Cat. #IT-25) as a positive control, and mouse IgG-SAP (Cat. #IT-18) as a negative control. The 7E4B11-SAP conjugate displayed significant antitumor activity in mice engrafted with U87 glioma cells.
Related Products: Mab-ZAP (Cat. #IT-04), Anti-DAT-SAP (Cat. #IT-25), Mouse IgG-SAP (Cat. #IT-18), Custom Conjugates
Estradiol and orexin-2 saporin actions on multiple forms of behavioral arousal in female mice.
Easton A, Dwyer E, Pfaff DW (2006) Estradiol and orexin-2 saporin actions on multiple forms of behavioral arousal in female mice. Behav Neurosci 120(1):1-9. doi: 10.1037/0735-7044.120.1.1
Summary: Many aspects of female behavioral arousal in response to estrogens are not yet well understood. Here the authors examine the role of orexins as targets for estrogens. Female mice were treated with 10 ng of orexin-SAP (Cat. #IT-20) into each hemisphere of the lateral hypothalamus. The mice were then tested in different modes of behavioral arousal. Mice treated with orexin-SAP displayed decreases in sensory responsiveness and fearfulness concomitant with a reduction in orexin cell number.
Related Products: Orexin-B-SAP (Cat. #IT-20)
A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells.
O’Connell PJ, Wang X, Leon-Ponte M, Griffiths C, Pingle SC, Ahern GP (2006) A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells. Blood 107(3):1010-1017. doi: 10.1182/blood-2005-07-2903 PMID: 16223770
Related Products: Antibody to Serotonin Transporter (SERT, Cat. #AB-N09)
Estrogen contributes to structural recovery after a lesion.
Saenz C, Dominguez R, de Lacalle S (2006) Estrogen contributes to structural recovery after a lesion. Neurosci Lett 392(3):198-201. doi: 10.1016/j.neulet.2005.09.023
Summary: The authors evaluated the trophic effects of 17ß-estradiol (E2) on cholinergic neurons of the basal forebrain after lesioning with 192-IgG-SAP (Cat. #IT-01). Ovariectomized female rats received 200 nl of 0.075 mg/ml 192-IgG-SAP followed by a subcutaneous pellet of E2, which was released over 60 days. Dendritic size in ovariectomized rats receiving the E2 was the same as in control animals, while ovariectomized rats receiving a placebo displayed a significant reduction in dendritic arborization.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability.
Li A, Nattie E (2006) Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability. J Physiol 570(Pt 2):385-396. doi: 10.1113/jphysiol.2005.099325
Summary: Brainstem catecholamine (CA) neurons are thought to modulate the processing of sensory information and participate in the control of breathing. Using a 5 µg injection of anti-DBH-SAP (Cat. #IT-03), or a control injection of mouse-IgG-SAP (Cat. #IT-18) into the fourth ventricle, the authors investigated breathing frequency and wakefulness. The results suggest that CA neurons promote wakefulness, participate in central respiratory chemoreception, stimulate breathing frequency, and minimize breathing variability during REM sleep.
Related Products: Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18)
Possible role of CRF peptides in burn-induced hypermetabolism.
Chance WT, Dayal R, Friend LA, Sheriff S (2006) Possible role of CRF peptides in burn-induced hypermetabolism. Life Sci 78(7):694-703. doi: 10.1016/j.lfs.2005.05.083
Summary: Burn trauma has been associated with hypermetabolism and anorexia. Corticotropin releasing factor (CRF) elevates metabolic rate and elicits anorexia, while neuropeptide Y (NPY) reduces metabolic rate while stimulating feeding. After burn treatment, rats were injected with 2.5 µg CRF-SAP (Cat. #IT-13) into the third ventricle. Several parameters, including resting energy expenditure, NPY concentrations in the paraventricular nucleus, and CRFr-2 density were evaluated post-treatment. The results indicate that the CRFr-2 is important in maintaining hypermetabolism resulting from burn trauma.
Related Products: CRF-SAP (Cat. #IT-13)
Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons.
Emgard M, Paradisi M, Pirondi S, Fernandez M, Giardino L, Calza L (2007) Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons. Neurobiol Aging 28(1):112-121. doi: 10.1016/j.neurobiolaging.2005.11.015
Summary: Women at risk of preterm delivery are commonly treated with synthetic glucocorticoids such as dexamethasone and betamethasone. Here the authors examined adult rats that were prenatally exposed to glucocorticoids. After 2.5 µg intracerebroventricular injections of 192-IgG-SAP (Cat. #IT-01) or 0.44 µg of saporin (Cat. #PR-01), the rats were tested in a water maze pool. The evidence suggests that not only do prenatal glucocorticoids affect adult cognitive function, they also make cholinergic neurons more susceptible to challenges later in life.
Related Products: 192-IgG-SAP (Cat. #IT-01), Saporin (Cat. #PR-01)
Featured Article: The biologically active cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, retains high affinity for CCK2 receptors after covalent conjugation to saporin
Lai J, Zhang W, Badghisi H, Hruby VJ, Porreca F (2006) Featured Article: The biologically active cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, retains high affinity for CCK2 receptors after covalent conjugation to saporin. Targeting Trends 7(1)
Related Products: CCK-SAP (Cat. #IT-31)
Read the featured article in Targeting Trends.
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