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Advanced Targeting Systems is pleased to announce the arrival of its newest second immunotoxin, Rat-ZAP (Cat. #IT-26). This new screening agent is constructed from goat anti-rat IgG conjugated to saporin. Like the other second immunotoxins, Hum-ZAP, Mab-ZAP and Rab-ZAP, it converts your primary antibody, in this case a rat IgG, into a potent cytotoxic agent […]

Advanced Targeting Systems announces the availability of two monoclonal antibodies to the dopamine transporter (DAT). These antibodies have become a standard for work on DAT and have already played a prominent role in the characterization of the dopamine transporter. The two antibodies are rat monoclonals, so they can be excellent for multiple staining protocols. Anti-DAT-NT, Cat.

a chemical conjugate of avidin and the ribosome-inactivating protein, saporin Avidin is a glycoprotein found in egg white and in tissues of birds, reptiles, and amphibians. This protein is composed of four subunits, each of which can bind one molecule of biotin. Biotin, a 244-dalton vitamin found in tissue and blood, binds with high affinity to

Even though it only became available recently, Dermorphin-SAP (Cat. #IT-12) has already begun to help researchers unlock the mysteries of brain function. Dermorphin-SAP is a chemical conjugate between an analog of the frog skin peptide dermorphin and the ribosome- inactivating protein saporin. Dermorphin, a peptide of seven amino acids characterized by Ersparmer and his colleagues,1

Advanced Targeting Systems announces the release of two reagents for immunological studies: Anti-Tac (Cat. # AB-18) – a monoclonal antibody to human CD25, the interleukin-2 receptor, and Anti-Tac-SAP (Cat. # IT-24) – the immunotoxin made by conjugation of anti-Tac to saporin. These reagents add to the growing list of ATS products for use in studies

OX7-SAP is a cytotoxin to many types of neurons. It is one of the most potent of the saporin immunotoxins— the conjugates between a cell surface antibody and the ribosome-inactivating protein from Saponaria officinalis. The reason for the potency could be due to the construct’s grand tradition. The antibody, OX7, is one of the original

Advanced Targeting Systems announces a new reagent for the study of the serotonergic systems—a monoclonal antibody to the serotonin transporter (Cat. #AB-N09). This murine monoclonal is made with a peptide from an extracellular domain of rat serotonin re-uptake transporter (SERT), and thus is able to attach to cells that express SERT. Homology with the human

Work on hypocretin, or orexin, as it is also known, is some of the most interesting in all of biology these days. When first characterized a mere three years ago by two groups, it was thought to be involved in feeding (hence the name orexin from the Greek orexis meaning appetite). But two articles exploded

Saporin is a 30 kDa protein isolated from the seeds of the plant Saponaria officinalis. This pleasant resident of the banks of Southern European streams has long been known for medicinal properties, mainly due to its saponins, detergents that reside especially in the roots of the plant and which give the plant its name. It

Advanced Targeting Systems announces two new control molecules for use with immunotoxins. We now offer mouse IgG (Cat. #IT-18) or rat IgG (Cat. #IT-17) conjugated to saporin. These new controls are the same molecular weight, consist of similar, comparable materials — saporin and a rat or mouse IgG — and are synthesized with the same