Targeting Topics

Acute Effects of Alcohol on Sleep Are Mediated by Components of Homeostatic Sleep Regulatory System: An Editorial Highlight for ‘Lesions of the Basal Forebrain Cholinergic Neurons Attenuates Sleepiness and Adenosine after Alcohol Consumption.’ Alam, MN, & McGinty, D. (2017). J Neurochem 2017/07/25. In the study, titled ‘Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and […]

Validation and Characterization of a Novel Method for Selective Vagal Deafferentation of the Gut. Diepenbroek C, Quinn D, Stephens R, Zollinger B, Anderson S, Pan A, de Lartigue G. Am J Physiol Gastrointest Liver Physiol 2017. PMID: 28705805 The authors Injected CCK-SAP (Cat. #IT-31) into the nodose ganglia (NG) of rats to specifically ablate GI‐VAN

ATS is in Booth 114 at the Alzheimer’s Association International Conference in London this week. Did you know that table tennis is widely reported to be an effective therapy for patients with Alzheimer’s Disease? This was news to us, but made us even more happy for ATS associates to be playing every Friday afternoon. Check

Cholinergic input to the hippocampus is not required for episodic memory in the rat, even with multiple consecutive events.S. Seel, M.J. Eacott, A. Easton. Behav Brain Res 2017. PMID: 28601587   The authors use 192-IgG-SAP (Cat. #IT-01) to examine episodic memory. Continual trials versions of an episodic memory task are unimpaired by cholinergic lesions of the medial septum. In contrast continual

Sonic Hedgehog and TDP-43 Participate in the Spontaneous Locomotor Recovery in a Mouse Model of Spinal Motoneuron Disease.  Rosario Gulino *, Rosalba Parenti and Massimo Gulisano J. Funct. Morphol. Kinesiol. 2017, 2(2), 11; doi:10.3390/jfmk2020011 The authors used a mouse model of neurotoxic motoneuron depletion to study the role of Sonic hedgehog and TDP-43 in the compensatory changes occurring

Role of A5 noradrenergic neurons in the chemoreflex control of respiratory and sympathetic activities in unanesthetized conditions. Camilia L Taxini, Thiago S Moreira, Ana C Takakura, Daniel B Zoccal. Neuroscience 354:146-157, 2017. PMID: 28461215 The authors utilize Anti-DBH-SAP (Cat. #IT-03) to investigate the involvement of the A5 noradrenergic neurons to the basal and chemoreflex control of the sympathetic

Targeting Cholinergic Neurons with 192-IgG-SAP Lee et al. examined the effects of chronic stress on changes in spatial learning and underlying molecular signaling induced by cholinergic depletion. Previous studies revealed that loss of cholinergic input to the hippocampus reduces the expression of glucocorticoid receptors (GRs) and activates nuclear factor-kappa B (NF-κB) signaling through interactions with

In a study produced by Ferrini et al. indicates that morphine-induced hyperalgesia, as neuropathic pain, is a pathological alteration of pain sensitivity whose expression is gated by spinal microglia. Targeting at any level, this microglia-to-neuron cascade is a valuable strategy to improve the use of morphine in chronic pain. Ferrini F, Trang T, Mattioli TA,

When as little as five micrograms of Neuropeptide Y (NPY) are infused into the third ventricle of a rat, that rat will eat five times more than a normal amount of food over the subsequent two hours.  An effective technique to confirm that leptin specifically acts upon NPY-containing neurons to depress feeding is to infuse

Congratulations to the research team at Harry S. Truman Memorial Veterans Hospital and Department of Neurology, University of Missouri, Columbia, MO, for their publication in Journal of Neurochemistry.  Their interesting project examined the sleep-promoting effect of alcohol and which neurons in the brain are involved in the process. Lesions of the basal forebrain cholinergic neurons