Author name: Kristen Hartman

Identification of a novel perifornical-hypothalamic-area-projecting serotonergic system that inhibits innate panic and conditioned fear responses

Bernabe CS, Caliman IF, de Abreu ARR, Molosh AI, Truitt WA, Shekhar A, Johnson PL (2024) Identification of a novel perifornical-hypothalamic-area-projecting serotonergic system that inhibits innate panic and conditioned fear responses. Transl Psychiatry 14(1):60. doi: 10.1038/s41398-024-02769-3 PMID: 38272876 Objective: To investigate the role of serotonergic inputs from the raphe nuclei to the perifornical hypothalamic area […]

Identification of a novel perifornical-hypothalamic-area-projecting serotonergic system that inhibits innate panic and conditioned fear responses Read More »

Characterizing a new tool to manipulate area postrema GLP1R+ neurons across species

Fulton S, Horn CC, Zhang C (2024) Characterizing a new tool to manipulate area postrema GLP1R+ neurons across species. Physiol Behav 114474. doi: 10.1016/j.physbeh.2024.114474 PMID: 38272107 Objective: Characterize the ligand exenatide conjugated to saporin as a tool to ablate GLP1 receptor-expressing cells from human, mice, and shrews, a small animal model capable of emesis (vomiting).

Characterizing a new tool to manipulate area postrema GLP1R+ neurons across species Read More »

Etonogestrel promotes respiratory recovery in an in vivo rat model of central chemoreflex impairment

Janes TA, Cardani S, Saini JK, Pagliardini S (2024) Etonogestrel promotes respiratory recovery in an in vivo rat model of central chemoreflex impairment. Acta Physiol (Oxf) e14093. doi: 10.1111/apha.14093 PMID: 38258900 Objective: Examine the use of progestins and synthetic progestins in the stimulation of breathing, especially after chemoreflexive impairment. Summary: Central CO2 chemoreflex is important

Etonogestrel promotes respiratory recovery in an in vivo rat model of central chemoreflex impairment Read More »

Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution

Donovan LJ, Bridges CM, Nippert AR, Wang M, Wu S, Forman TE, Haight ES, Huck NA, Bond SF, Jordan CE, Gardner AM, Nair RV, Tawfik VL (2024) Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution. Cell Rep 43(2):113683. doi: 10.1016/j.celrep.2024.113683 PMID: 38261512 Objective: To study the role of microglia in

Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution Read More »

Crosstalk between colorectal CSCs and immune cells in tumorigenesis, and strategies for targeting colorectal CSCs

Zhao Q, Zong H, Zhu P, Su C, Tang W, Chen Z, Jin S (2024) Crosstalk between colorectal CSCs and immune cells in tumorigenesis, and strategies for targeting colorectal CSCs. Exp Hematol Oncol 13(1):6. doi: 10.1186/s40164-024-00474-x PMID: 38254219 Summary: Cancer immunotherapy has become a promising strategy in the treatment of colorectal cancer, and relapse after

Crosstalk between colorectal CSCs and immune cells in tumorigenesis, and strategies for targeting colorectal CSCs Read More »

A role of frontal association cortex in long-term object recognition memory of objects with complex features in rats

Masmudi-Martín M, López-Aranda MF, Navarro-Lobato I, Khan ZU (2024) A role of frontal association cortex in long-term object recognition memory of objects with complex features in rats. Eur J Neurosci 59(7):1743-1752. doi: 10.1111/ejn.16243 PMID: 38238909 Objective: Provide evidence that the frontal association cortex and not the Perirhinal cortex is essential for object recognition memory (ORM)

A role of frontal association cortex in long-term object recognition memory of objects with complex features in rats Read More »

Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin

Allred CA, Gormley C, Venugopal I, Li S, McGuire MJ, Brown KC (2023) Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin. Commun Biol 6(1):60. doi: 10.1038/s42003-022-04385-7 PMID: 36650239 Objective: The demonstration of a peptide optimized by chemical modifications for tumor specificity to deliver saporin, a catalytic toxin, specifically to cancer cells via both in

Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin Read More »

New methods to investigate the GnRH pulse generator

Ivanova D, O’Byrne KT (2024) New methods to investigate the GnRH pulse generator. J Mol Endocrinol 72(2):e230079. doi: 10.1530/JME-23-0079 PMID: 38085702 Objective: To review the latest methodologies and insights into the GnRH pulse generator and its role in regulating reproductive hormone secretion. Summary: The paper discusses recent advancements in understanding the GnRH pulse generator and

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Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice

Maiarù M, Leese C, Silva-Hucha S, Fontana-Giusti S, Tait L, Tamagnini F, Davletov B, Hunt SP (2024) Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice. J Pain 25(6):104466. doi: 10.1016/j.jpain.2024.01.331 PMID: 38218509 Summary: The authors discuss how Substance P-Botulinum is used to

Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice Read More »

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