Author name: Kristen Hartman

Cell lineage tracing identifies hormone-regulated and wnt-responsive vaginal epithelial stem cells

Ali A, Syed SM, Jamaluddin MFB, Colino-Sanguino Y, Gallego-Ortega D, Tanwar PS (2020) Cell lineage tracing identifies hormone-regulated and wnt-responsive vaginal epithelial stem cells. Cell Rep 30(5):1463-1477.e7. doi: 10.1016/j.celrep.2020.01.003 PMID: 32023462 Objective: To learn more about the role of Wnt signaling in vaginal epithelium (VE) homeostasis. Summary: Data define heterogeneity in VE and identify VE […]

Cell lineage tracing identifies hormone-regulated and wnt-responsive vaginal epithelial stem cells Read More »

More than scratching the surface: recent progress in brain mechanisms underlying itch and scratch.

Liu X, Miao XH, Liu T (2020) More than scratching the surface: recent progress in brain mechanisms underlying itch and scratch. Neurosci Bull 36(1):85-88. doi: 10.1007/s12264-019-00352-1 Summary: The discovery of descending neural circuitry to drive the itch-scratching cycle may provide potential therapeutic targets in the central nervous system for the management of chronic itch. Usage:

More than scratching the surface: recent progress in brain mechanisms underlying itch and scratch. Read More »

Quantum dot conjugated saporin activates microglia and induces selective substantia nigra degeneration.

Landrigan J, Dwyer Z, Beauchamp S, Rodriguez R, Fortin T, Hayley S (2020) Quantum dot conjugated saporin activates microglia and induces selective substantia nigra degeneration. NeuroToxicology 76:153-161. doi: 10.1016/j.neuro.2019.11.007 PMID: 31738977 Objective: To assess the impact of Quantum Dots (QDs) alone and QDs conjugated to Saporin, on substantia nigra microglia and dopamine neurons. Summary: QDs

Quantum dot conjugated saporin activates microglia and induces selective substantia nigra degeneration. Read More »

Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure

Moreira da Silva Santos A, Gorman AM, Kelly JP, Doyle KM (2020) Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure. Neurosci Lett 715:134606. doi: 10.1016/j.neulet.2019.134606 PMID: 31693929 Objective: To investigate the effect of binge-like methamphetamine (MA) dosing on brain-derived neurotrophic factor (BDNF) levels and

Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure Read More »

ALPPL2 is a highly specific and targetable tumor cell surface antigen

Su Y, Zhang X, Bidlingmaier S, Behrens CR, Lee NK, Liu B (2020) ALPPL2 is a highly specific and targetable tumor cell surface antigen. Cancer Res 80(20):4552-4564. doi: 10.1158/0008-5472.CAN-20-1418 PMID: 32868383 Objective: To evaluate therapeutic potential of ALPPL2 targeting. Summary: Exquisite tissue specificity and broad tumor type coverage suggest that ALPPL2 could be an excellent

ALPPL2 is a highly specific and targetable tumor cell surface antigen Read More »

Adenosine 2A receptor inhibition protects phrenic motor neurons from cell death induced by protein synthesis inhibition.

Seven YB, Simon AK, Sajjadi E, Zwick A, Satriotomo I, Mitchell GS (2020) Adenosine 2A receptor inhibition protects phrenic motor neurons from cell death induced by protein synthesis inhibition. Exp Neurol 323:113067. doi: 10.1016/j.expneurol.2019.113067 Objective: To test the hypothesis that A2A receptor antagonism promotes phrenic motor neuron survival and preserves diaphragm function when faced with

Adenosine 2A receptor inhibition protects phrenic motor neurons from cell death induced by protein synthesis inhibition. Read More »

Ptps facilitates compartmentalized LTBP1 S-nitrosylation and promotes tumor growth under hypoxia

Zhao Q, Zheng K, Ma C, Li J, Zhuo L, Huang W, Chen T, Jiang Y (2020) Ptps facilitates compartmentalized LTBP1 S-nitrosylation and promotes tumor growth under hypoxia. Mol Cell 77(1):95-107.e5. doi: 10.1016/j.molcel.2019.09.018 PMID: 31628042 Objective: To investigate whether there is a molecular mechanism underlying the regulation of LTBP1-TGF-b signaling by the BH4-biosynthesis pathway. Summary:

Ptps facilitates compartmentalized LTBP1 S-nitrosylation and promotes tumor growth under hypoxia Read More »

Cover Article: Targeted Toxins – Cheaper and Quicker than Knockouts

News Article /

Cell-specific targeting and removal: cheaper and quicker than knockouts with high impact results. Knockout models are helpful tools in scientific research. They have been useful in studying and modeling in all sorts of research in biology; so much so that the pioneers – Smithies, Capecchi and Evans – won a well-deserved Nobel Prize for Physiology

Cover Article: Targeted Toxins – Cheaper and Quicker than Knockouts Read More »

Novel Autoimmune IgM Antibody Attenuates Atherosclerosis in IgM Deficient Low-Fat Diet-Fed, but Not Western Diet-Fed Apoe-/- Mice

Cherepanova OA, Srikakulapu P, Greene ES, Chaklader M, Haskins RM, McCanna ME, Bandyopadhyay S, Ban B, Leitinger N, McNamara CA, Owens GK (2020) Novel Autoimmune IgM Antibody Attenuates Atherosclerosis in IgM Deficient Low-Fat Diet-Fed, but Not Western Diet-Fed Apoe-/- Mice. Arterioscler Thromb Vasc Biol 40(1):206-219. doi: 10.1161/ATVBAHA.119.312771 PMID: 31645128 Related Products: Antibody to OxPL (10C12)

Novel Autoimmune IgM Antibody Attenuates Atherosclerosis in IgM Deficient Low-Fat Diet-Fed, but Not Western Diet-Fed Apoe-/- Mice Read More »

Episodic stimulation of central chemoreceptor neurons elicits disordered breathing and autonomic dysfunction in volume overload heart failure.

Díaz HS, Andrade DC, Toledo C, Pereyra KV, Schwarz KG, Díaz-Jara E, Lucero C, Arce-Álvarez A, Schultz HD, Silva JN, Takakura AC, Moreira TS, Marcus NJ, Del Rio R (2020) Episodic stimulation of central chemoreceptor neurons elicits disordered breathing and autonomic dysfunction in volume overload heart failure. Am J Physiol Lung Cell Mol Physiol 318(1):L27-L40.

Episodic stimulation of central chemoreceptor neurons elicits disordered breathing and autonomic dysfunction in volume overload heart failure. Read More »

Search
Shopping Cart
Scroll to Top