Zhao Q, Zheng K, Ma C, Li J, Zhuo L, Huang W, Chen T, Jiang Y (2020) Ptps facilitates compartmentalized LTBP1 S-nitrosylation and promotes tumor growth under hypoxia. Mol Cell 77(1):95-107.e5. doi: 10.1016/j.molcel.2019.09.018 PMID: 31628042
Objective: To investigate whether there is a molecular mechanism underlying the regulation of LTBP1-TGF-b signaling by the BH4-biosynthesis pathway.
Summary: GTP cyclohydrolase I (GTPCH), 6-pyruvoyltetrahydropterin synthase (PTPS), and sepiapterin reductase (SR) are sequentially responsible for de novo synthesis of tetrahydrobiopterin (BH4), a known cofactor for nitric oxide synthase (NOS). PTPS metabolic activity is required for colorectal tumor cell growth under hypoxia.
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