Author name: Kristen Hartman

Inflammatory macrophages facilitate mechanical stress-induced osteogenesis.

Zhang F, Huan L, Xu T, Li G, Zheng B, Zhao H, Guo Y, Shi J, Sun J, Chen A (2020) Inflammatory macrophages facilitate mechanical stress-induced osteogenesis. Aging (Albany NY) 12(4):3617-3625. doi: 10.18632/aging.102833 Summary: In a mouse model of distraction osteogenesis (DO), there was significant increase in macrophages in the regeneration area. This suggests that […]

Inflammatory macrophages facilitate mechanical stress-induced osteogenesis. Read More »

Fugan Wan alleviates hepatic fibrosis by inhibiting ACE/Ang II/AT-1R signaling pathway and enhancing ACE2/Ang 1-7/Mas signaling pathway in hepatic fibrosis rat models

Li S, Zhao W, Tao Y, Liu C (2020) Fugan Wan alleviates hepatic fibrosis by inhibiting ACE/Ang II/AT-1R signaling pathway and enhancing ACE2/Ang 1-7/Mas signaling pathway in hepatic fibrosis rat models. Am J Transl Res 12(2):592-601. PMID: 32194907 Objective: To investigate protective effects of Fugan Wan (FGW) on hepatic fibrosis and clarify associated mechanisms. Summary:

Fugan Wan alleviates hepatic fibrosis by inhibiting ACE/Ang II/AT-1R signaling pathway and enhancing ACE2/Ang 1-7/Mas signaling pathway in hepatic fibrosis rat models Read More »

Intervening B-type natriuretic peptide signaling for controlling chronic itch.

Meng J, Chen W, Wang J (2020) Intervening B-type natriuretic peptide signaling for controlling chronic itch. Brit J Pharmacol 177(5):1025-1040. doi: 10.1111/bph.14952 Objective: Review of recent findings used to examine the role of B-type natriuretic peptide (BNP) in itch transduction and the modulation of other pururitic proteins. Summary: Mice treated with Nppb-SAP ablated 70% of

Intervening B-type natriuretic peptide signaling for controlling chronic itch. Read More »

Voltage-gated calcium channel subunit α2δ-3 shapes light responses of mouse retinal ganglion cells mainly in low and moderate light levels

Seitter H, Sothilingam V, Benkner B, Garrido MG, Kling A, Pirone A, Seeliger M, Münch TA (2020) Voltage-gated calcium channel subunit α2δ-3 shapes light responses of mouse retinal ganglion cells mainly in low and moderate light levels. bioRxiv 2020.02.10.941807. doi: 10.1101/2020.02.10.941807 Related Products: Melanopsin Rabbit Polyclonal, affinity-purified (Cat. #AB-N39)

Voltage-gated calcium channel subunit α2δ-3 shapes light responses of mouse retinal ganglion cells mainly in low and moderate light levels Read More »

nGnG amacrine cells and Brn3b-negative M1 ipRGCs are specifically labeled in the ChAT-ChR2-EYFP mouse.

Cui LJ, Chen WH, Liu AL, Han X, Jiang SX, Yuan F, Zhong YM, Yang XL, Weng SJ (2020) nGnG amacrine cells and Brn3b-negative M1 ipRGCs are specifically labeled in the ChAT-ChR2-EYFP mouse. Invest Ophthalmol Vis Sci 61(2):14. doi: 10.1167/iovs.61.2.14 PMID: 32049344 Summary: The authors speculated that type II cells might be ipRGCs. This was

nGnG amacrine cells and Brn3b-negative M1 ipRGCs are specifically labeled in the ChAT-ChR2-EYFP mouse. Read More »

Cell lineage tracing identifies hormone-regulated and wnt-responsive vaginal epithelial stem cells

Ali A, Syed SM, Jamaluddin MFB, Colino-Sanguino Y, Gallego-Ortega D, Tanwar PS (2020) Cell lineage tracing identifies hormone-regulated and wnt-responsive vaginal epithelial stem cells. Cell Rep 30(5):1463-1477.e7. doi: 10.1016/j.celrep.2020.01.003 PMID: 32023462 Objective: To learn more about the role of Wnt signaling in vaginal epithelium (VE) homeostasis. Summary: Data define heterogeneity in VE and identify VE

Cell lineage tracing identifies hormone-regulated and wnt-responsive vaginal epithelial stem cells Read More »

More than scratching the surface: recent progress in brain mechanisms underlying itch and scratch.

Liu X, Miao XH, Liu T (2020) More than scratching the surface: recent progress in brain mechanisms underlying itch and scratch. Neurosci Bull 36(1):85-88. doi: 10.1007/s12264-019-00352-1 Summary: The discovery of descending neural circuitry to drive the itch-scratching cycle may provide potential therapeutic targets in the central nervous system for the management of chronic itch. Usage:

More than scratching the surface: recent progress in brain mechanisms underlying itch and scratch. Read More »

Quantum dot conjugated saporin activates microglia and induces selective substantia nigra degeneration.

Landrigan J, Dwyer Z, Beauchamp S, Rodriguez R, Fortin T, Hayley S (2020) Quantum dot conjugated saporin activates microglia and induces selective substantia nigra degeneration. NeuroToxicology 76:153-161. doi: 10.1016/j.neuro.2019.11.007 PMID: 31738977 Objective: To assess the impact of Quantum Dots (QDs) alone and QDs conjugated to Saporin, on substantia nigra microglia and dopamine neurons. Summary: QDs

Quantum dot conjugated saporin activates microglia and induces selective substantia nigra degeneration. Read More »

Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure

Moreira da Silva Santos A, Gorman AM, Kelly JP, Doyle KM (2020) Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure. Neurosci Lett 715:134606. doi: 10.1016/j.neulet.2019.134606 PMID: 31693929 Objective: To investigate the effect of binge-like methamphetamine (MA) dosing on brain-derived neurotrophic factor (BDNF) levels and

Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure Read More »

ALPPL2 is a highly specific and targetable tumor cell surface antigen

Su Y, Zhang X, Bidlingmaier S, Behrens CR, Lee NK, Liu B (2020) ALPPL2 is a highly specific and targetable tumor cell surface antigen. Cancer Res 80(20):4552-4564. doi: 10.1158/0008-5472.CAN-20-1418 PMID: 32868383 Objective: To evaluate therapeutic potential of ALPPL2 targeting. Summary: Exquisite tissue specificity and broad tumor type coverage suggest that ALPPL2 could be an excellent

ALPPL2 is a highly specific and targetable tumor cell surface antigen Read More »

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