Author name: Kristen Hartman

Purification of fibroblasts from the spiral ganglion

Anacker A, Esser KH, Lenarz T, Paasche G (2022) Purification of fibroblasts from the spiral ganglion. Front Neurol 13:877342. doi: 10.3389/fneur.2022.877342 PMID: 35493807 Objective: To provide a purified preparation of cochlear fibroblasts, which can be used in vitro for further investigations. Summary: Subcultivation of the primary spiral ganglion cells culture removed the neurons from the […]

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Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer’s disease

Liu W, Li J, Yang M, Ke X, Dai Y, Lin H, Wang S, Chen L, Tao J (2022) Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer’s disease. Alzheimers Res Ther 14(1):53. doi: 10.1186/s13195-022-00994-w Related Products: 192-IgG-SAP (Cat. #IT-01) See Also: Tomaszewicz M et al. Changes in cortical

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P2X7 receptor augments LPS-induced nitrosative stress by regulating Nrf2 and GSH levels in the mouse hippocampus

Lee DS, Kim JE (2022) P2X7 receptor augments LPS-induced nitrosative stress by regulating Nrf2 and GSH levels in the mouse hippocampus. Antioxidants (Basel) 11(4):778. doi: 10.3390/antiox11040778 PMID: 35453462 Objective: To elucidate whether P2X7R affects nuclear factor-erythroid 2-related factor 2 (Nrf2) activity/expression and glutathione (GSH) synthesis under nitrosative stress in response to lipopolysaccharide (LPS)-induced neuroinflammation. Summary:

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A novel RGD-4C-saporin conjugate inhibits tumor growth in mouse models of bladder cancer

Zuppone S, Assalini C, Minici C, Botrugno OA, Curnis F, Degano M, Corti A, Montorsi F, Salonia A, Vago R (2022) A novel RGD-4C-saporin conjugate inhibits tumor growth in mouse models of bladder cancer. Front Oncol 12:846958. doi: 10.3389/fonc.2022.846958 PMID: 35480108 Objective: To explore the anti-tumor activity of the RGD-SAP in vitro and in vivo,

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Intrinsically photosensitive retinal ganglion cells evade temporal filtering to encode environmental light intensity

Sabbah S, Papendorp C, Behrendt I, Rasras H, Cann J, Leyrer ML, Koplas E, Beltoja M, Etebari C, Gunesch AN, Carrete L, Kim MT, Manoff G, Bhatia-Lin A, Zhao T, Dowling H, Briggman KL, Berson DM (2022) Intrinsically photosensitive retinal ganglion cells evade temporal filtering to encode environmental light intensity. bioRxiv 2022.04.09.487733. doi: 10.1101/2022.04.09.487733 Related

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Top 20 Targeting Tools of 2021

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Top Five Targeted Toxins #1. CTB-SAP  (Cat. #IT-14) – targets cells expressing GM1 receptor #2 Mac-1-SAP (Cat. #IT-06) – targets cells expressing Mac-1 (CD11b ) receptor #3 Anti-CD103-SAP (Cat. #IT-50) – targets cells expressing CD103 #4. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase  #5. mu p75-SAP (Cat. #IT-16) – targets cells expressing mouse

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Targeted Ablation with IB4-SAP

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Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis Kayla L. Nguyen1, Sydney R. Lamerand1, Ronit P. Deshpande1, Bradley K. Taylor1,2 1Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA2Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA

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