Zuppone S, Assalini C, Minici C, Botrugno OA, Curnis F, Degano M, Corti A, Montorsi F, Salonia A, Vago R (2022) A novel RGD-4C-saporin conjugate inhibits tumor growth in mouse models of bladder cancer. Front Oncol 12:846958. doi: 10.3389/fonc.2022.846958 PMID: 35480108
Objective: To explore the anti-tumor activity of the RGD-SAP in vitro and in vivo, using a model of muscle invasive bladder cancer.
Summary: The authors demonstrated RGD-SAP conjugate can be easily produced in E.coli with no need of renaturation, and that this product can kill integrin-expressing cells more efficiently than a SAP variant lacking the RGD domain. Moreover, we show that RGD-SAP can inhibit the tumor growth in mouse models of bladder cancer.
Usage: Saporin used as positive control (PR-01)
Related Products: Saporin (Cat. #PR-01)