Author name: Kristen Hartman

Behavioural, histological and immunocytochemical consequences following 192 IgG-Saporin immunolesions of the basal forebrain cholinergic system.

Perry T, Hodges H, Gray JA (2001) Behavioural, histological and immunocytochemical consequences following 192 IgG-Saporin immunolesions of the basal forebrain cholinergic system. Brain Res Bull 54(1):29-48. doi: 10.1016/s0361-9230(00)00413-5 Summary: 192-Saporin (Cat. #IT-01) has been used extensively as a model for Alzheimer’s Disease. The neuronal deficits caused by intraparenchymal forebrain injections (0.3-0.51 µg/µl) are apparent during […]

Behavioural, histological and immunocytochemical consequences following 192 IgG-Saporin immunolesions of the basal forebrain cholinergic system. Read More »

Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of a2B adrenoceptors.

Sawamura S, Kingery WS, Davies MF, Agashe GS, Clark JD, Kobilka BK, Hashimoto T, Maze M (2000) Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of a2B adrenoceptors. J Neurosci 20(24):9242-9251. doi: 10.1523/JNEUROSCI.20-24-09242.2000 Summary: Nitrous oxide has been used extensively in surgical anesthesia for more than

Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of a2B adrenoceptors. Read More »

Cholinergic basal forebrain is critical for social transmission of food preferences

Berger-Sweeney J, Stearns NA, Frick KM, Beard B, Baxter MG (2000) Cholinergic basal forebrain is critical for social transmission of food preferences. Hippocampus 10(6):729-738. doi: 10.1002/1098-1063(2000)10:63.0.CO;2-M PMID: 11153718 Objective: To examine whether the cholinergic basal forebrain plays a role in non-spatial associative memory, specifically, the social transmission of food preferences. Summary: The authors lesioned rats

Cholinergic basal forebrain is critical for social transmission of food preferences Read More »

Up-regulation of growth-associated protein 43 mRNA in rat medial septum neurons axotomized by fimbria-fornix transection.

Haas CA, Hollerbach E, Deller T, Naumann T, Frotscher M (2000) Up-regulation of growth-associated protein 43 mRNA in rat medial septum neurons axotomized by fimbria-fornix transection. Eur J Neurosci 12:4233-4242. doi: 10.1046/j.0953-816x.2000.01329.x Summary: Axonal growth and regeneration is limited in adult mammals, however, if injured CNS neurons are in an environment permissive for growth, they

Up-regulation of growth-associated protein 43 mRNA in rat medial septum neurons axotomized by fimbria-fornix transection. Read More »

Cortical cholinergic inputs mediate processing capacity: Effects of 192 IgG-saporin-induced lesions on olfactory span performance.

Turchi J, Sarter M (2000) Cortical cholinergic inputs mediate processing capacity: Effects of 192 IgG-saporin-induced lesions on olfactory span performance. Eur J Neurosci 12:4505-4514. Summary: Many experiments support the theory that the basal forebrain (BF) is involved in major aspects of attention that influence learning and memory. Elimination of cholinergic neurons in the BF by

Cortical cholinergic inputs mediate processing capacity: Effects of 192 IgG-saporin-induced lesions on olfactory span performance. Read More »

Non-linear cortico-cortical interactions modulated by cholinergic afferences from the rat basal forebrain.

Villa AEP, Tetko IV, Dutoit P, Vantini G (2000) Non-linear cortico-cortical interactions modulated by cholinergic afferences from the rat basal forebrain. BioSystems 58:219-228. doi: 10.1016/s0303-2647(00)00126-x Summary: Elimination of the cholinergic neurons of the basal forebrain (BF) is an excellent model for some aspects of Alzheimer’s Disease (AD). 192-Saporin (Cat. #IT-01) is a very effective tool

Non-linear cortico-cortical interactions modulated by cholinergic afferences from the rat basal forebrain. Read More »

Central cholinergic depletion induced by 192 IgG-saporin alleviates the sedative effects of propofol in rats.

Pain L, Jeltsch H, Lehmann O, Lazarus C, Laalou FZ, Cassel JC (2000) Central cholinergic depletion induced by 192 IgG-saporin alleviates the sedative effects of propofol in rats. Brit J Anaesth 85(6):869-873. doi: 10.1093/bja/85.6.869 Summary: In order to examine the effect of cholinergic depletion on the sedative potency of propofol in rats the authors injected

Central cholinergic depletion induced by 192 IgG-saporin alleviates the sedative effects of propofol in rats. Read More »

Neuronal lesioning with axonally transported toxins.

Wiley RG, Kline IV RH (2000) Neuronal lesioning with axonally transported toxins. J Neurosci Methods 103:73-82. doi: 10.1016/S0165-0270(00)00297-1 Summary: Functional neuroanatomy studies have long utilized lesioning. Given the complexity of heterogeneous neuron populations conventional lesioning methods have proved relatively crude, and have provided limited information. Wiley and Kline detail some of the immunotoxins utilizing saporin

Neuronal lesioning with axonally transported toxins. Read More »

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