Lappi DA, Wiley RG (2000) Entering through the doors of perception: characterization of a highly selective Substance P receptor-targeted toxin. Neuropeptides 34(5):323-328. doi: 10.1054/npep.2000.0827 Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12)
Beach T (2000) Featured Article: CBF lesioning in rabbits. Targeting Trends 1(1) Related Products: ME20.4-SAP (Cat. #IT-15) Read the featured article in Targeting Trends. See Also: Beach TG et al. Cholinergic deafferentation of the rabbit cortex: a new animal model of Abeta deposition. Neurosci Lett 283:9-12, 2000.
Featured Article: CBF lesioning in rabbits Read More »
In April of this year ATS applied for funding from National Institute for Mental Health (NIMH) for the toxicology studies of Substance P-Saporin (SP-SAP). This $674,000 supplement to a previous NIMH Small Business Innovative Research grant will cover one of the FDA-required safety and toxicology studies and will bring us closer to clinical trials in
Chronic Pain Therapeutic Read More »
Advanced Targeting Systems (ATS) has just been awarded a $100,000 research grant from the National Institute on Drug Abuse (NIDA). This Phase I SBIR (Small Business Innovation Research) grant proposes to develop a research reagent to study the function of the neuropeptide, galanin. This will be an important tool for scientists to use in the
NIDA funds ATS research on Galanin Read More »
Contributed by Dr. Thomas Beach, Sun Health Research Institute, Sun City, AZ Our hypothesis, developed through our own human and animal studies1-6 and the cell culture work of others (beginning with Nitsch7), is that the normal, age-related loss of cortical cholinergic innervation leads to Aβ deposition and Alzheimer’s disease. To test this hypothesis, we have been
Cover Article: CBF Lesioning in Rabbits Read More »
Silveira DC, Holmes GL, Schachter SC, Geula C, Schomer DL (2000) Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats. Brain Res 878:223-227. doi: 10.1016/s0006-8993(00)02703-7 Usage: 192-SAP (Cat. #IT-01), 4 µg intracerebroventricular injection Related Products: 192-IgG-SAP (Cat. #IT-01)
Taylor BK, Roderick RE, Basbaum AI (2000) Brainstem noradrenergic control of nociception is abnormal in the spontaneously hypertensive rat. Neurosci Lett 291:139-142. doi: 10.1016/s0304-3940(00)01389-6 Usage: anti-DBH-SAP (Cat. #IT-03), 5 µg Related Products: Anti-DBH-SAP (Cat. #IT-03)
Wiley RG (2000) Neuropeptide-toxin conjugates in pain research and treatment. (Review). Reg Anesth Pain Med 25(5):546-548. doi: 10.1053/rapm.2000.8457 Summary: Several lines of evidence indicate dorsal horn neurons that respond to substance P (SP) play a role in nociception. Wiley discusses the attributes of SP-SAP (Cat. #IT-07), a targeted toxin that eliminates cells expressing the neurokinin-1
Neuropeptide-toxin conjugates in pain research and treatment. (Review) Read More »
McNerney ME, Pardi D, Pugh PC, Nai Q, Margiotta JF (2000) Expression and channel properties of alpha-bungarotoxin-sensitive acetylcholine receptors on chick ciliary and choroid neurons. J Neurophysiol 84(3):1314-1329. doi: 10.1152/jn.2000.84.3.1314 PMID: 10980005 Related Products: Nicotinic Acetylcholine Receptor alpha 1 (mAb 35) Rat Monoclonal (Cat. #AB-N36)
Bannerman P, Nichols W, Puhalla S, Oliver T, Berman M, Pleasure D (2000) Early migratory rat neural crest cells express functional gap junctions: Evidence that neural crest cell survival requires gap junction function. J Neurosci Res 61:605-615. doi: 10.1002/1097-4547(20000915)61:63.0.CO;2-U PMID: 10972957 Summary: Gap junctions are vital for intercellular communication, especially during development. Neural crest cells