Safety Instructions Good laboratory technique must be employed for the safe handling of this product. This requires observation of the following practices: 1. Wear appropriate laboratory attire, including lab coat, gloves and safety glasses. 2. Do not pipet by mouth, inhale, ingest or allow product to come into contact with open wounds. Wash thoroughly any […]
Lappi DA (2002) Featured Article: Control conjugates: The perfect companion for targeted toxins. Targeting Trends 3(1) Related Products: Rat IgG-SAP (Cat. #IT-17), Mouse IgG-SAP (Cat. #IT-18), Goat IgG-SAP (Cat. #IT-19), Blank-SAP (Cat. #IT-21) Read the featured article in Targeting Trends.
Featured Article: Control conjugates: The perfect companion for targeted toxins Read More »
Dr. Douglas Lappi, Chief Scientific Officer, Advanced Targeting Systems The field of targeted toxins has made enormous strides in the years since Advanced Targeting Systems introduced the first research targeted toxin in 1994. We now offer 16 different targeted toxins, with more on the way. The number of important papers in high impact journals continues
Cover Article: Control Conjugates – The Perfect Companion for Targeted Toxins Read More »
Read the 2001 Newsletters and recent scientific references 2001, issue 1: Immunolesioning: From Spinal Cord to Brain / by Schreihofer A / featuring Anti-DBH-SAP (Cat. #IT-03) Jennifer Martin wins “ATS Abstract of the Year Award” Targeting Talk: In vivo Use of Targeted Toxins Targeting Tools: IB4-SAP 2001, issue 2: Safety Studies Begin for Chronic Pain Therapeutic Targeting
Targeting Trends 2001 Newsletter Read More »
Cahill JFX, Baxter MG (2001) Cholinergic and noncholinergic septal neurons modulate strategy selection in spatial learning. Eur J Neurosci 14:1856-1864. doi: 10.1046/j.0953-816x.2001.01807.x Summary: The authors compared ibotenic acid (IA)-treated rats with those injected with 45 ng and 30 ng of 192-Saporin (Cat. #IT-01) into two separate coordinates of the medial septum/vertical limb of the diagonal
Lamprea MR, Cardenas FP, Silveira R, Morato S, Walsh TJ (2000) Dissociation of memory and anxiety in a repeated elevated plus maze paradigm: Forebrain cholinergic mechanisms. Behav Brain Res 117:97-105. doi: 10.1016/s0166-4328(00)00294-1 Summary: The septo-hippocampal pathway has been implicated in many behavioral processes such as learning, anxiety, and motivation. Using 192-Saporin (Cat. #IT-01) to lesion
Ballmaier M, Casamenti F, Zoli M, Pepeu G, Spano P (2001) Selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis impairs prepulse inhibition of acoustic startle. Neuroscience 108(2):299-305. doi: 10.1016/s0306-4522(01)00413-4 Summary: One of the measures for schizophrenia is a deficit in sensorimotor gating (the ability of the brain to filter sensory input to focus on
Himmelheber AM, Sarter M, Bruno JP (2001) The effects of manipulations of attentional demand on cortical acetylcholine release. Brain Res Cogn Brain Res 12(3):353-370. doi: 10.1016/s0926-6410(01)00064-7 Summary: Cortical cholinergic afferents from the basal forebrain are suspected to be involved in attentional tasks. Regulatory impairment of these afferents has been hypothesized to contribute to attentional deficits
The effects of manipulations of attentional demand on cortical acetylcholine release. Read More »
Vogt LJ, Sim-Selley LJ, Childers SR, Wiley RG, Vogt BA (2001) Colocalization of mu-opioid receptors and activated G-proteins in rat cingulate cortex. J Pharmacol Exper Ther 299:840-848. Summary: The anterior cingulate cortex (ACC) is a primary site of opiate drug action, and much of this activity is associated with the m-opioid receptor (MOR). The mechanisms
Colocalization of mu-opioid receptors and activated G-proteins in rat cingulate cortex. Read More »
Vulchanova L, Olson TH, Stone LS, Riedl MS, Elde R, Honda CN (2001) Cytotoxic targeting of isolectin IB4-binding sensory neurons. Neuroscience 108(1):143-155. doi: 10.1016/s0306-4522(01)00377-3 PMID: 11738138 Summary: Vulchanova et al. examine the role of IB4-binding neurons in nociception. IB4-SAP (Cat. #IT-10) was injected into rats (2 µg in left sciatic nerve). The resulting ablation of
Cytotoxic targeting of isolectin IB4-binding sensory neurons. Read More »