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  4. Unilateral lesions of the cholinergic Basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys.

Unilateral lesions of the cholinergic Basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys.

Easton A, Ridley RM, Baker HF, Gaffan D (2002) Unilateral lesions of the cholinergic Basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys. Cereb Cortex 12(7):729-736. doi: 10.1093/cercor/12.7.729

Summary: The authors used a combination of basal forebrain lesioning using ME20.4-SAP (Cat. #IT-15) and surgery to isolate the inferior temporal cortex and medial temporal cortex from cholinergic afferents in rhesus monkeys. Testing of the treated animals demonstrated severe impairments in learning visual scenes and object-reward associations.

Related Products: ME20.4-SAP (Cat. #IT-15)

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