Author name: Kristen Hartman

Flp-recombinase mouse line for genetic manipulation of ipRGCs

Contreras E, Liang C, Mahoney HL, Javier JL, Luce ML, Labastida Medina K, Bozza T, Schmidt TM (2024) Flp-recombinase mouse line for genetic manipulation of ipRGCs. bioRxiv doi: 10.1101/2024.05.06.592761 PMID: 38766000 Objective: To report the generation and characterization of a new mouse line (Opn4FlpO), in which FlpO is expressed from the Opn4 locus, to manipulate […]

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Extra-hippocampal contributions to social memory: The role of septal nuclei

Shivakumar AB, Mehak SF, Jijimon F, Gangadharan G (2024) Extra-hippocampal contributions to social memory: The role of septal nuclei. Biol Psychiatry 6:835-847. doi: 10.1016/j.biopsych.2024.04.018 PMID: 38718881 Objective: Review neural circuit mechanisms that underlie social memory, with a special emphasis on the septum. Summary: Understanding the complexities of the septohippocampal axis will allow targeted therapies to

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Activation of alpha 2 adrenergic receptor of cerebrospinal fluid-contacting nucleus alleviates acute incision pain behavior in rats

Meng XT, Song SY, Li Y, Peng S, Zhang LC (2024) Activation of alpha 2 adrenergic receptor of cerebrospinal fluid-contacting nucleus alleviates acute incision pain behavior in rats. Research Square doi: 10.21203/rs.3.rs-4258857/v1 Objective: To study the effects of Dexmedetomidine (DEX) on pain modulation. Summary: Dexmedetomidine is an alpha 2-adrenergic receptor agonist with sedative, analgesic, and

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Development of chemically induced choroidal injury models for the study and treatment of AMD

Han I, Pandala N, Haefeli L, Lang MJ, Stone EM, Mullins RF, Tucker BA (2024) Development of chemically induced choroidal injury models for the study and treatment of AMD. ARVO Annual Meeting 65(7):5382. Objective: To describe the development of Age-Related Macular Degeneration (AMD) models through the targeted injury of choroidal cells in the eye. Summary:

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iPSC derived choroidal endothelial cell delivery using laminin-based hydrogels for the treatment of AMD

Pandala N, Han I, Meyering E, Stone EM, Mullins RF, Tucker BA (2024) iPSC derived choroidal endothelial cell delivery using laminin-based hydrogels for the treatment of AMD. ARVO Annual Meeting 65(7):1542. Objective: To demonstrate an interventional therapy for age-related macular degeneration (AMD) using a rat model. Summary: In this study, induced pluripotent stem cells (iPSCs)

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Unveiling cholera toxin binding and intoxication using enteroids and site-specific mutants

Boucher A (2024) Unveiling cholera toxin binding and intoxication using enteroids and site-specific mutants. Univ Gothenburg Thesis. Objective: To investigate the binding site requirements of cholera toxin in the human body. Summary: The cause of cholera symptoms is cholera toxin secreted by bacteria once in the small intestine. Cholera toxin has multiple binding sites that

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Striatal parvalbumin interneurons are activated in a mouse model of cerebellar dystonia

Matsuda T, Morigaki R, Hayasawa H, Koyama H, Oda T, Miyake K, Takagi Y (2024) Striatal parvalbumin interneurons are activated in a mouse model of cerebellar dystonia. Dis Model Mech 17(5):dmm050338. doi: 10.1242/dmm.050338 PMID: 38616770 Objective: To examine the influence of cerebellar abnormalities on the basal ganglia circuitry to investigate dystonia pathophysiology. Summary: Dystonia is

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A pupillary contrast response in mice and humans: Neural mechanisms and visual functions

Fitzpatrick MJ, Krizan J, Hsiang JC, Shen N, Kerschensteiner D (2024) A pupillary contrast response in mice and humans: Neural mechanisms and visual functions. Neuron doi: 10.1016/j.neuron.2024.04.012 PMID: 38697114 Objective: To show that temporal contrast drives pupil constriction through a cell-type-specific retinal circuit in mice and humans. Summary: The pupillary contrast response enhances high spatial

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Cancer Research

Targeting Topics /

Antibody Drug Conjugates to Treat Cancer A Brief History of Saporin and its Contributions to Neuroscience Targeted Toxins – Cheaper and Quicker than Knockouts A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors. Screening targeting agents and their cell surface biomarkers for high

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An ascending vagal sensory-central noradrenergic pathway modulates retrieval of passive avoidance memory

Edwards CM, Guerrero IE, Thompson D, Dolezel T, Rinaman L (2024) An ascending vagal sensory-central noradrenergic pathway modulates retrieval of passive avoidance memory. bioRxiv 2024.04.09.588717. doi: 10.1101/2024.04.09.588717 PMID: 38645069 Objective: To investigate the role of a gut vagal afferent-to-central noradrenergic pathway in modulating the retrieval of conditioned passive avoidance memory in rats. Summary: This study

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