Author name: Kristen Hartman

Blanco-Centurion CA, Salin-Pascual R, Gerashchenko D, Greco MA, Lappi DA, Kilduff TS, Shiromani PJ (2000) DBH-saporin lesions the locus coeruleus, but does not produce cataplexy or abnormal REM sleep triggering. Neuroscience 2000 Abstracts 566.17. Society for Neuroscience, New Orleans, LA. Summary: Recently, canine narcolepsy was associated with a mutation in the hypocretin-2 receptor (Lin et […]

Ritter S, Dinh TT, Bugarith K (2000) Anti-dβh-saporin injection into the paraventricular nucleus of the hypothalamus selectively abolishes 2DG-induced feeding without causing nonspecific tissue destruction. Neuroscience 2000 Abstracts 502.8. Society for Neuroscience, New Orleans, LA. Summary: The toxin-antibody complex, saporin conjugated to a monoclonal antibody against dopamine-β-hydroxylase (anti-dβh-sap), selectively destroys dβh-containing catecholamine neurons. Previously we

Siddiq MM, Tsirka SE (2000) Elimination of microglia suggests their involvement in neuronal plasticity. Neuroscience 2000 Abstracts 507.2. Society for Neuroscience, New Orleans, LA. Summary: Reorganization of mossy fibers occurs in the mammalian hippocampus during consolidation of learning and memory. Induced low level seizures with kainic acid (KA) result in the development of new synapses

Rogers SD, Salak-Johnson JL, Schwei MJ, Pomonis JD, Mantyh PW (2000) Reduced anxiety related behavior following ablation of amygdala neurons expressing substance P receptor. Neuroscience 2000 Abstracts 571.2. Society for Neuroscience, New Orleans, LA. Summary: The neurokinin substance P (SP) is localized in brain regions that coordinate stress response and may play a role in

Janni G, Moallem T, Lappi DA, Ohara PT, Jasmin L (2000) Schwann cells are removed from the rat spinal cord after effecting recovery from paraplegia. Neuroscience 2000 Abstracts 516.8. Society for Neuroscience, New Orleans, LA. Summary: Remyelination of the CNS is necessary to restore neural function in a number of demyelinating conditions such as multiple

Berger-Sweeney JE, Murg SL, Baxter MG, Stearns NA, Lappi DA (2000) A specific cholinergic immunotoxin in mice. Neuroscience 2000 Abstracts 563.13. Society for Neuroscience, New Orleans, LA. Summary: We have shown previously that 192 IgG-saporin, a p75 (nerve growth factor [NGF] receptor) antibody linked to the ribosome-inactivating protein saporin, is an effective lesioning agent for

Gerashchenko D, Greco MA, Salin-Pascual R, Kilduff TS, Lappi DA, Shiromani PJ (2000) Orexin-B conjugated to saporin lesions LH and TMN neurons and produces narcoleptic-like sleep in rats. Neuroscience 2000 Abstracts 566.27. Society for Neuroscience, New Orleans, LA. Summary: A dysfunction of the hypocretin/orexin (Hcrt/Ox) system was recently linked with the sleep disorder, narcolepsy. To

Vulchanova L, Olson TH, Elde R, Honda CN (2000) Role of IB4-binding sensory neurons in the effects of intradermal capsaicin injection. Neuroscience 2000 Abstracts 212.7. Society for Neuroscience, New Orleans, LA. Summary: We have shown previously that a unilateral injection of a conjugate of the lectin IB4 and the toxin saporin (IB4-SAP) into sciatic nerve

Martin JL, Sloviter RS (2000) Focal hippocampal hyperexcitability after focal interneuron ablation in the rat by substance P-saporin. Neuroscience 2000 Abstracts 389.13. Society for Neuroscience, New Orleans, LA. Summary: Hyperexcitability after prolonged seizures or head trauma may result from interneuron malfunction or loss; but a causal relationship is in doubt because global insults produce widespread

Miller SA, Lappi DA, Wiley RG (2000) Intrathecal dermorphin-saporin decreases morphine effect in hotplate algesia testing. Neuroscience 2000 Abstracts 212.8. Society for Neuroscience, New Orleans, LA. Summary: The targeted cytotoxin, dermorphin-saporin, selectively destroys cells expressing MOR. In the present study, we gave dermorphin-saporin by lumbar i.t. injection and sought to determine if destroying dorsal horn