Author name: Kristen Hartman

Contribution of the cholinergic basal forebrain to proactive interference from stored odor memories during associative learning in rats.

de Rosa E, Hasselmo ME, Baxter MG (2001) Contribution of the cholinergic basal forebrain to proactive interference from stored odor memories during associative learning in rats. Behav Neurosci 115(2):314-327. Summary: Proactive interference (PI) is the damaging effect of previously learned information on the acquisition of new, related information. Human patients with basal forebrain (BF) damage […]

Contribution of the cholinergic basal forebrain to proactive interference from stored odor memories during associative learning in rats. Read More »

Selective destruction of medial septal cholinergic neurons attenuates pyramidal cell suppression, but not excitation in dorsal hippocampus field CA1 induced by subcutaneous injection of formalin.

Zheng F, Khanna S (2001) Selective destruction of medial septal cholinergic neurons attenuates pyramidal cell suppression, but not excitation in dorsal hippocampus field CA1 induced by subcutaneous injection of formalin. Neuroscience 103(4):985-998. doi: 10.1016/s0306-4522(01)00006-9 Summary: Previously, the authors have shown that an injection of formalin in the hindpaw of rats will excite a select population

Selective destruction of medial septal cholinergic neurons attenuates pyramidal cell suppression, but not excitation in dorsal hippocampus field CA1 induced by subcutaneous injection of formalin. Read More »

Safety Studies Begin

Early last month (March 2001), Advanced Targeting Systems (ATS) received funding from the National Institute of Mental Health (NIMH) to begin toxicology/safety studies of Substance P-Saporin (SP-SAP), a potential therapeutic for the treatment of chronic pain. The studies will be completed under the direction of three scientists who are experts in their respective fields. Dr.

Safety Studies Begin Read More »

It’s enough to raise your blood pressure!

Deuchars J, Deuchars S (2001) It’s enough to raise your blood pressure!. Trends Neurosci 24(4):200. doi: 10.1016/s0166-2236(00)01800-2 Summary: The authors review studies completed by Schreihofer and Guyenet using anti-DBH-SAP (Cat. #IT-03) to eliminate C1 adrenergic neurons. The results show that, although C1 neurons play a role in some sympathoexcitatory responses, they are probably not responsible

It’s enough to raise your blood pressure! Read More »

Development of a method for intraparenchymal infusions of 192 IgG-Saporin: a comment on Pizzo et al. (1999) [letter; comment]

Sarter M, Bruno JP, Miner LA, McGaughy J (2000) Development of a method for intraparenchymal infusions of 192 IgG-Saporin: a comment on Pizzo et al. (1999) [letter; comment]. J Neurosci Methods 96:169-170. doi: 10.1016/s0165-0270(99)00196-x PMID: 10720682 Summary: Letter pertaining to use of 192-SAP Related Products: 192-IgG-SAP (Cat. #IT-01) See Also: Pizzo DP et al. Intraparenchymal

Development of a method for intraparenchymal infusions of 192 IgG-Saporin: a comment on Pizzo et al. (1999) [letter; comment] Read More »

Characterization of immunoglobulin binding to isolated human erythrocyte membranes: evidence for selective, temperature-induced binding of naturally occurring autoantibodies to the cytoskeleton.

Salhany JM, Cordes KS, Sloan RL (2001) Characterization of immunoglobulin binding to isolated human erythrocyte membranes: evidence for selective, temperature-induced binding of naturally occurring autoantibodies to the cytoskeleton. Biochim Biophys Acta 1511(1):168-180. doi: 10.1016/s0005-2736(01)00280-2 PMID: 11248215 Related Products: 192-IgG Mouse Monoclonal, Alexa488-labeled (Cat. #AB-N43FLA)

Characterization of immunoglobulin binding to isolated human erythrocyte membranes: evidence for selective, temperature-induced binding of naturally occurring autoantibodies to the cytoskeleton. Read More »

Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation.

Ritter S, Bugarith K, Dinh TT (2001) Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation. J Comp Neurol 432(2):197-216. doi: 10.1002/cne.1097 Summary: Control of regulatory responses to low glucose levels in the brain have been linked to catecholaminergic neurons. Studies of these neurons have been hindered by the

Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation. Read More »

Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: comparison with noradrenergic neurons.

Ferencz I, Leanza G, Nonobashvili A, Kokaia Z, Kokaia M, Lindvall O (2001) Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: comparison with noradrenergic neurons. Neuroscience 102(4):819-832. doi: 10.1016/s0306-4522(00)00499-1 Summary: Kindling can be caused in rats by lesioning forebrain cholinergic or noradrenergic projections. Ferencz et al. utilize 192-Saporin (2.5 µg; Cat. #IT-01)

Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: comparison with noradrenergic neurons. Read More »

p75-expressing elements are necessary for anti-allodynic effects of spinal clonidine and neostigmine.

Paqueron X, Li X, Eisenach JC (2001) p75-expressing elements are necessary for anti-allodynic effects of spinal clonidine and neostigmine. Neuroscience 102(3):681-686. doi: 10.1016/s0306-4522(00)00528-5 Summary: It has been suggested that alpha2-adrenergic agonists produce analgesia by activating spinal cholinergic neurons. The authors reason that since spinal cholinergic neurons in the ventral horn express p75 following peripheral nerve

p75-expressing elements are necessary for anti-allodynic effects of spinal clonidine and neostigmine. Read More »

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