Ferencz I, Leanza G, Nonobashvili A, Kokaia Z, Kokaia M, Lindvall O (2001) Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: comparison with noradrenergic neurons. Neuroscience 102(4):819-832. doi: 10.1016/s0306-4522(00)00499-1
Summary: Kindling can be caused in rats by lesioning forebrain cholinergic or noradrenergic projections. Ferencz et al. utilize 192-Saporin (2.5 µg; Cat. #IT-01) to lesion forebrain cholinergic neurons and 6-hydroxydopamine to lesion noradrenergic neurons, administering both compounds by intraventricular injection. Upon comparing various aspects of hippocampal kindling, the authors determine that while both noradrenergic and cholinergic projections to the forebrain exert inhibitory effects, the cholinergic effect is less pronounced and occurs prior to seizure generalization.
Related Products: 192-IgG-SAP (Cat. #IT-01)