Author name: Kristen Hartman

Modulation of photic resetting in rats by lesions of projections to the suprachiasmatic nuclei expressing p75 neurotrophin receptor.

Erhardt C, Galani R, Jeltsch H, Cassel JC, Klosen P, Menet JS, Pevet P, Challet E (2004) Modulation of photic resetting in rats by lesions of projections to the suprachiasmatic nuclei expressing p75 neurotrophin receptor. Eur J Neurosci 19(7):1773-1788. doi: 10.1111/j.1460-9568.2004.03281.x Summary: The circadian clock in mammals is located within suprachiasmatic nuclei of the hypothalamus […]

Modulation of photic resetting in rats by lesions of projections to the suprachiasmatic nuclei expressing p75 neurotrophin receptor. Read More »

Targeting Tools: Anti-Tac (CD25)-SAP

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Advanced Targeting Systems has introduced important new toxins for investigation into cells that express the interleukin-2 (IL-2) receptor and especially the workings of the immune system. Anti-CD25-saporin (Anti-Tac-SAP) conjugates are directed to the human IL-2 receptor or to the mouse IL-2 receptor. This marker for activated T lymphocytes allows removal of this important group of

Targeting Tools: Anti-Tac (CD25)-SAP Read More »

Streptavidin versus Avidin

Q: I recently tried to order avidinylated-SAP (Cat. #IT-09) and was told that this product has been replaced with a new product, Streptavidin-ZAP (Cat. #IT-27). Why did you replace avidinylated-SAP? A: We initially had good results with avidinylated-SAP. It combined well with biotinylated antibody to produce extremely potent cytotoxic materials, and had low toxicity itself.

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Featured Article: 192 IgG-saporin-induced lesions identify an inhibitory role in cocaine reward for cholinergic neuronal systems in the diagonal band and ventral pallidum

Smith J (2004) Featured Article: 192 IgG-saporin-induced lesions identify an inhibitory role in cocaine reward for cholinergic neuronal systems in the diagonal band and ventral pallidum. Targeting Trends 5(2) Related Products: 192-IgG-SAP (Cat. #IT-01) Read the featured article in Targeting Trends. See Also: Smith JE et al. Involvement of cholinergic neuronal systems in intravenous cocaine

Featured Article: 192 IgG-saporin-induced lesions identify an inhibitory role in cocaine reward for cholinergic neuronal systems in the diagonal band and ventral pallidum Read More »

Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis

Pehar M, Cassina P, Vargas MR, Castellanos R, Viera L, Beckman JS, Estévez AG, Barbeito L (2004) Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis. J Neurochem 89(2):464-473. doi: 10.1111/j.1471-4159.2004.02357.x PMID: 15056289 Summary: The role of p75-mediated activity evaluated with p75NTR blocking antibody. Motor neuron loss induced by

Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis Read More »

Cover Article: 192 IgG-Saporin-Induced Lesions Identify an Inhibitory Role in Cocaine Reward for Cholinergic Neuronal Systems in the Diagonal Band and Ventral Pallidum

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Contributed by Dr. James Smith, Wake Forest University School of Medicine, Department of Physiology and Pharmacology, Medical Center Blvd, Winston-Salem NC 27157 Recent data implicate cholinergic neurons in the brain processes that underlie reinforcement. The involvement of cholinergic neurons in cocaine self-administration has been recently demonstrated using muscarinic and nicotinic agonists and antagonists, microdialysis, assessment

Cover Article: 192 IgG-Saporin-Induced Lesions Identify an Inhibitory Role in Cocaine Reward for Cholinergic Neuronal Systems in the Diagonal Band and Ventral Pallidum Read More »

Medullary serotonergic neurons and adjacent neurons that express neurokinin-1 receptors are both involved in chemoreception in vivo.

Nattie EE, Li A, Richerson GB, Lappi DA (2004) Medullary serotonergic neurons and adjacent neurons that express neurokinin-1 receptors are both involved in chemoreception in vivo. J Physiol 556(1):235-253. doi: 10.1113/jphysiol.2003.059766 PMID: 14724193 Summary: The retrotrapezoid nucleus contains neurokinin-1 receptor (NK-1r)-expressing neurons that are involved in chemoreception. NK-1r-expressing neurons are also present in areas that

Medullary serotonergic neurons and adjacent neurons that express neurokinin-1 receptors are both involved in chemoreception in vivo. Read More »

Habituation to stress and dexamethasone suppression in rats with selective basal forebrain cholinergic lesions.

Helm KA, Ziegler DR, Gallagher M (2004) Habituation to stress and dexamethasone suppression in rats with selective basal forebrain cholinergic lesions. Hippocampus 14(5):628-635. doi: 10.1002/hipo.10203 Summary: Basal forebrain cholinergic neurons may be involved in hippocampal and medial prefrontal cortex inhibition of glucocorticoid stress responses. The authors investigated the effects of 0.05 to 0.075 µg injections

Habituation to stress and dexamethasone suppression in rats with selective basal forebrain cholinergic lesions. Read More »

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