Yezierski RP, Yu CG, Mantyh PW, Vierck CJ, Lappi DA (2004) Spinal neurons involved in the generation of at-level pain following spinal injury in the rat. Neurosci Lett 361(1-3):232-236. doi: 10.1016/j.neulet.2003.12.035 Summary: The elimination of substance P receptor-expressing neurons in lamina I of the spinal cord using SP-SAP (Cat. #IT-07) has been shown to reduce […]
Jasmin L, Ohara PT (2004) Recurrent paraplegia after remyelination of the spinal cord. J Neurosci Res 77(2):277-284. doi: 10.1002/jnr.20143 Summary: Previously, the authors demonstrated that a 3 µg-injection of CTB-SAP (Cat. #IT-14) into the lumbosacral intrathecal space caused a loss of motor function due to spinal demyelination. The motor function was recovered and stable for
Recurrent paraplegia after remyelination of the spinal cord. Read More »
Mattsson A, Pernold K, Ogren SO, Olson L (2004) Loss of cortical acetylcholine enhances amphetamine-induced locomotor activity. Neuroscience 127(3):579-591. doi: 10.1016/j.neuroscience.2004.05.038 Summary: The authors have recently shown that cholinergic denervation of the basal forebrain in rats leads to an increased motor response to d-amphetamine, a hallmark of schizophrenia. In the present study 192-Saporin (Cat. #IT-01)
Loss of cortical acetylcholine enhances amphetamine-induced locomotor activity. Read More »
Margeta M, Ohara PT, Bollen AW, Jasmin L (2004) Intrathecal application of saporin conjugates leads to development of pituitary adenomas in rats. J Neuropathol Exp Neurology 63(5):518. Objective: To study the recovery from spinal cord demyelination or the effects of decreased central noradrenergic tone on pain behavior. Summary: The spectrum of findings varied from small,
Rajakumar N, Leung LS, Ma J, Rajakumar B, Rushlow W (2004) Altered neurotrophin receptor function in the developing prefrontal cortex leads to adult-onset dopaminergic hyperresponsivity and impaired prepulse inhibition of acoustic startle. Biol Psychiatry 55(8):797-803. doi: 10.1016/j.biopsych.2003.12.015 Summary: Neurodevelopmental abnormalities are suspected to play a role in the pathogenesis of schizophrenia. The authors injected 0.75
Erhardt C, Galani R, Jeltsch H, Cassel JC, Klosen P, Menet JS, Pevet P, Challet E (2004) Modulation of photic resetting in rats by lesions of projections to the suprachiasmatic nuclei expressing p75 neurotrophin receptor. Eur J Neurosci 19(7):1773-1788. doi: 10.1111/j.1460-9568.2004.03281.x Summary: The circadian clock in mammals is located within suprachiasmatic nuclei of the hypothalamus
We have re-designed the anti-murine p75-Saporin targeted toxin (mu p75-SAP, Cat. #IT-16) and have produced a conjugate that is much more potent in our in vitro cell cytotoxicity assays. Previously, we used a rat monoclonal antibody. This antibody had been outperformed by our rabbit polyclonal AB-N01, in several assays, especially FACS analysis of murine p75-expressing
Targeting Tools: mu p75-SAP Improved Read More »
Advanced Targeting Systems has introduced important new toxins for investigation into cells that express the interleukin-2 (IL-2) receptor and especially the workings of the immune system. Anti-CD25-saporin (Anti-Tac-SAP) conjugates are directed to the human IL-2 receptor or to the mouse IL-2 receptor. This marker for activated T lymphocytes allows removal of this important group of
Targeting Tools: Anti-Tac (CD25)-SAP Read More »
Q: I recently tried to order avidinylated-SAP (Cat. #IT-09) and was told that this product has been replaced with a new product, Streptavidin-ZAP (Cat. #IT-27). Why did you replace avidinylated-SAP? A: We initially had good results with avidinylated-SAP. It combined well with biotinylated antibody to produce extremely potent cytotoxic materials, and had low toxicity itself.
Streptavidin versus Avidin Read More »
Smith J (2004) Featured Article: 192 IgG-saporin-induced lesions identify an inhibitory role in cocaine reward for cholinergic neuronal systems in the diagonal band and ventral pallidum. Targeting Trends 5(2) Related Products: 192-IgG-SAP (Cat. #IT-01) Read the featured article in Targeting Trends. See Also: Smith JE et al. Involvement of cholinergic neuronal systems in intravenous cocaine