Author name: Kristen Hartman

Neurotrophic modulation of cholinergic denervation and hippocampal sympathetic ingrowth following immunolesioning with 192 IgG-saporin

Kolasa K, Parsons D, Conger K, Harrell LE (2004) Neurotrophic modulation of cholinergic denervation and hippocampal sympathetic ingrowth following immunolesioning with 192 IgG-saporin. Neuroscience 2004 Abstracts 92.9. Society for Neuroscience, San Diego, CA. Summary: Injection of specific cholinotoxin, 192 IgG-saporin into the medial septum (MS)of rat induces not only a selective cholinergic denervation of hippocampus […]

Neurotrophic modulation of cholinergic denervation and hippocampal sympathetic ingrowth following immunolesioning with 192 IgG-saporin Read More »

Role of noradrenergic mechanisms in sustained attention, impulse control, and effects of methylphenidate in rats: Possible relevance to ADHD

Milstein JA, Lehmann O, Theobald DEH, Dalley JW, Robbins TW (2004) Role of noradrenergic mechanisms in sustained attention, impulse control, and effects of methylphenidate in rats: Possible relevance to ADHD. Neuroscience 2004 Abstracts 123.6. Society for Neuroscience, San Diego, CA. Summary: There has been renewed interest in noradrenergic (NA) modulation of sustained attention and impulse

Role of noradrenergic mechanisms in sustained attention, impulse control, and effects of methylphenidate in rats: Possible relevance to ADHD Read More »

Targeting Tools: CCK-SAP

News Tools /

CCK-SAP (Cat. #IT-31) This new targeted toxin is a chemical conjugate of sulfonated cholecystokinin (CCK) and the ribosome-inactivating protein, saporin. CCK is widely distributed in the central nervous system and the gastrointestinal tract. CCK-SAP is an effective tool to study eating disorders and pain transmission. CCK-SAP eliminates cells recognizing sulfonated CCK. All other cells are

Targeting Tools: CCK-SAP Read More »

Targeting Tools: NPY-SAP

News Tools /

NPY-SAP (Cat. #IT-28) NPY-SAP is a chemical conjugate of neuropeptide Y (NPY) and the ribosome-inactivating protein, saporin. NPY is the most abundant neuropeptide in the brain and is involved in many processes from prenatal to mature animals. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities,

Targeting Tools: NPY-SAP Read More »

Targeting Tools: Anti-M-ZAP

News Tools /

Anti-M-ZAP (Cat. #IT-30) Anti-M-ZAP is another product in the line of second immunotoxins. Second immunotoxins are conjugations of a secondary antibody to the ribosome-inactivating protein, saporin. The second immunotoxin uses the secondary antibody to “piggyback” onto YOUR primary antibody in order to evaluate the ability of the primary antibody to internalize. Anti-M-ZAP is a chemical

Targeting Tools: Anti-M-ZAP Read More »

Effective Toxins

Q: Why do your directions for SSP-SAP (Cat. #IT-11) state that it is to be used within hours after dissolution? To my knowledge, both proteins and peptides are stable in clean solution. A: In fact, the two components of SSP-SAP (Stable Substance P and Saporin) are quite stable. However, we have found that many things

Effective Toxins Read More »

Featured Article: Effects of IB4-SAP on bladder overactivity

Yoshimura N (2004) Featured Article: Effects of IB4-SAP on bladder overactivity. Targeting Trends 5(4) Related Products: IB4-SAP (Cat. #IT-10) Read the featured article in Targeting Trends. See Also: Nishiguchi J et al. Effects of isolectin B4-conjugated saporin, a targeting cytotoxin, on bladder overactivity induced by bladder irritation. Eur J Neurosci 20(2):474-482, 2004.

Featured Article: Effects of IB4-SAP on bladder overactivity Read More »

Cover Article: Effects of IB4-SAP on Bladder Overactivity

News Article /

Contributed by Dr. Naoki Yoshimura, Dept Urology/Pharmacology, Univ Pittsburgh School of Medicine, Pittsburgh PA 15213.Dr. Yoshimura summarizes his work with IB4-SAP. A complete report was published in Eur J Neurosci 20(2):474-482, 2004. It has been demonstrated that hyperexcitability of C-fibers in bladder afferent pathways can contribute to bladder overactivity and/or bladder pain under pathological conditions

Cover Article: Effects of IB4-SAP on Bladder Overactivity Read More »

Medullary noradrenergic neurons release norepinephrine in the medial amygdala in females in response to mating stimulation sufficient for pseudopregnancy.

Cameron NM, Carey P, Erskine MS (2004) Medullary noradrenergic neurons release norepinephrine in the medial amygdala in females in response to mating stimulation sufficient for pseudopregnancy. Brain Res 1022(1-2):137-147. doi: 10.1016/j.brainres.2004.07.022 Summary: Norepinephrine (NE) plays an important role in female reproductive function. While the ventral noradrenergic bundle is known to be necessary for transmitting the

Medullary noradrenergic neurons release norepinephrine in the medial amygdala in females in response to mating stimulation sufficient for pseudopregnancy. Read More »

Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in rats.

Gerashchenko D, Chou TC, Blanco-Centurion CA, Saper CB, Shiromani PJ (2004) Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in rats. Sleep 27(7):1275-1281. doi: 10.1093/sleep/27.7.1275 Summary: Although evidence suggests that histaminergic neurons in the tuberomammillary nucleus (TMN) promote wakefulness, this has not been investigated using specific lesioning agents. In this study, the

Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in rats. Read More »

Search
Shopping Cart
Scroll to Top