Author name: Kristen Hartman

Intrinsically photosensitive retinal ganglion cells evade temporal filtering to encode environmental light intensity

Sabbah S, Papendorp C, Behrendt I, Rasras H, Cann J, Leyrer ML, Koplas E, Beltoja M, Etebari C, Gunesch AN, Carrete L, Kim MT, Manoff G, Bhatia-Lin A, Zhao T, Dowling H, Briggman KL, Berson DM (2022) Intrinsically photosensitive retinal ganglion cells evade temporal filtering to encode environmental light intensity. bioRxiv 2022.04.09.487733. doi: 10.1101/2022.04.09.487733 Related […]

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Top 20 Targeting Tools of 2021

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Top Five Targeted Toxins #1. CTB-SAP  (Cat. #IT-14) – targets cells expressing GM1 receptor #2 Mac-1-SAP (Cat. #IT-06) – targets cells expressing Mac-1 (CD11b ) receptor #3 Anti-CD103-SAP (Cat. #IT-50) – targets cells expressing CD103 #4. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase  #5. mu p75-SAP (Cat. #IT-16) – targets cells expressing mouse

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Targeted Ablation with IB4-SAP

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Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis Kayla L. Nguyen1, Sydney R. Lamerand1, Ronit P. Deshpande1, Bradley K. Taylor1,2 1Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA2Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA

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Featured Article: Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis

Nguyen KL, Lamerand SR, Deshpande RP, Taylor BK (2021) Featured Article: Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis. Targeting Trends 22 Related Products: IB4-SAP (Cat. #IT-10), Blank-SAP (Cat. #IT-21) Read the featured article in Targeting Trends. See Also: Nguyen KL et al.

Featured Article: Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis Read More »

Top 20 Targeting Tools of 2020

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Top Five Targeted Toxins #1. CTB-SAP  (Cat. #IT-14) – targets cells expressing GM1 receptor #2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase  #3. IB4-SAP (Cat. #IT-10) – targets cells expressing alpha-D-galactopyranoside residues #4. mu p75-SAP (Cat. #IT-16) – targets cells expressing mouse p75NTR #5. ME20.4-SAP (Cat. #IT-15) – targets cells expressing multiple mammalian

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A spinal microglia population involved in remitting and relapsing neuropathic pain

Kohno K, Shirasaka R, Yoshihara K, Mikuriya S, Tanaka K, Takanami K, Inoue K, Sakamoto H, Ohkawa Y, Masuda T, Tsuda M (2022) A spinal microglia population involved in remitting and relapsing neuropathic pain. Science 376(6588):86-90. doi: 10.1126/science.abf6805 Objective: To investigate pain recovery mechanisms. Summary: The authors reveal a mechanism for the remission and recurrence

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Upregulation of p75NTR by histone deacetylase inhibitors sensitizes human neuroblastoma cells to targeted immunotoxin-induced apoptosis

Dedoni S, Olianas A, Manconi B, Collu M, Tuveri B, Vincis ME, Olianas MC, Onali P (2022) Upregulation of p75NTR by histone deacetylase inhibitors sensitizes human neuroblastoma cells to targeted immunotoxin-induced apoptosis. Int J Mol Sci 23(7):3849. doi: 10.3390/ijms23073849 PMID: 35409209 Summary: Histone deacetylase (HDAC) inhibitors have been useful chemotherapy agents in the treatment of

Upregulation of p75NTR by histone deacetylase inhibitors sensitizes human neuroblastoma cells to targeted immunotoxin-induced apoptosis Read More »

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