Author name: Kristen Hartman

Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model.

Foehr ED, Lorente G, Kuo J, Ram R, Nikolich K, Urfer R (2006) Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. Cancer Res 66(4):2271-2278. doi: 10.1158/0008-5472.CAN-05-1221 Summary: The receptor protein tyrosine phosphatase ß (RPTPß) is overexpressed in astrocytomas, and is a potential target for […]

Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. Read More »

Estradiol and orexin-2 saporin actions on multiple forms of behavioral arousal in female mice.

Easton A, Dwyer E, Pfaff DW (2006) Estradiol and orexin-2 saporin actions on multiple forms of behavioral arousal in female mice. Behav Neurosci 120(1):1-9. doi: 10.1037/0735-7044.120.1.1 Summary: Many aspects of female behavioral arousal in response to estrogens are not yet well understood. Here the authors examine the role of orexins as targets for estrogens. Female

Estradiol and orexin-2 saporin actions on multiple forms of behavioral arousal in female mice. Read More »

A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells.

O’Connell PJ, Wang X, Leon-Ponte M, Griffiths C, Pingle SC, Ahern GP (2006) A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells. Blood 107(3):1010-1017. doi: 10.1182/blood-2005-07-2903 PMID: 16223770 Related Products: Antibody to Serotonin Transporter (SERT, Cat. #AB-N09)

A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells. Read More »

Estrogen contributes to structural recovery after a lesion.

Saenz C, Dominguez R, de Lacalle S (2006) Estrogen contributes to structural recovery after a lesion. Neurosci Lett 392(3):198-201. doi: 10.1016/j.neulet.2005.09.023 Summary: The authors evaluated the trophic effects of 17ß-estradiol (E2) on cholinergic neurons of the basal forebrain after lesioning with 192-IgG-SAP (Cat. #IT-01). Ovariectomized female rats received 200 nl of 0.075 mg/ml 192-IgG-SAP followed

Estrogen contributes to structural recovery after a lesion. Read More »

Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability.

Li A, Nattie E (2006) Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability. J Physiol 570(Pt 2):385-396. doi: 10.1113/jphysiol.2005.099325 Summary: Brainstem catecholamine (CA) neurons are thought to modulate the processing of sensory information and participate in the control of breathing. Using a 5 µg injection of anti-DBH-SAP (Cat. #IT-03), or a

Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability. Read More »

Possible role of CRF peptides in burn-induced hypermetabolism.

Chance WT, Dayal R, Friend LA, Sheriff S (2006) Possible role of CRF peptides in burn-induced hypermetabolism. Life Sci 78(7):694-703. doi: 10.1016/j.lfs.2005.05.083 Summary: Burn trauma has been associated with hypermetabolism and anorexia. Corticotropin releasing factor (CRF) elevates metabolic rate and elicits anorexia, while neuropeptide Y (NPY) reduces metabolic rate while stimulating feeding. After burn treatment,

Possible role of CRF peptides in burn-induced hypermetabolism. Read More »

Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons.

Emgard M, Paradisi M, Pirondi S, Fernandez M, Giardino L, Calza L (2007) Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons. Neurobiol Aging 28(1):112-121. doi: 10.1016/j.neurobiolaging.2005.11.015 Summary: Women at risk of preterm delivery are commonly treated with synthetic glucocorticoids such as dexamethasone and betamethasone. Here the authors examined adult rats that were prenatally

Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons. Read More »

LPS Content

Q: In a recent experiment using a saporin-antibody conjugate injected systemically we saw changes in dendritic cells that could be consistent with an LPS effect. Does ATS test for LPS and has this ever been identified as a problem before? A: Yes, this can happen, but we here at ATS will swear innocence. One of

LPS Content Read More »

Featured Article: The biologically active cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, retains high affinity for CCK2 receptors after covalent conjugation to saporin

Lai J, Zhang W, Badghisi H, Hruby VJ, Porreca F (2006) Featured Article: The biologically active cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, retains high affinity for CCK2 receptors after covalent conjugation to saporin. Targeting Trends 7(1) Related Products: CCK-SAP (Cat. #IT-31) Read the featured article in Targeting Trends. See Also: Lai J et al. Featured Article: The

Featured Article: The biologically active cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, retains high affinity for CCK2 receptors after covalent conjugation to saporin Read More »

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