Wiley RG (2006) Featured Article: Targeted toxins in pain. Targeting Trends 7(2) Related Products: 192-IgG-SAP (Cat. #IT-01), Anti-DBH-SAP (Cat. #IT-03), Anti-SERT-SAP (Cat. #IT-23), SP-SAP (Cat. #IT-07), SSP-SAP (Cat. #IT-11), Dermorphin-SAP / MOR-SAP (Cat. #IT-12), Read the featured article in Targeting Trends.
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ATS continues to make progress toward human clinical trials with SP-SAP. Thanks to the financial support of the National Institutes of Health, National Institute of Mental Health, preclinical studies have been completed, protocols for drug production have been written and the first of two toxicology studies is done. This first study is a GLP toxicology
Chronic Pain Drug – Update on SP-SAP Development Read More »
Summary of contribution to “Recontres en toxinologie, 2005”by Ronald G. Wiley, Neurology Service (127) – VA TVHS, 1310 24th Avenue, South, Nashville, TN 37212 The use of targeted toxins in neuroscience research has evolved over the past twenty-plus years from original suicide transport lesions using ricin to highly selective neuron type-specific lesions made with immunotoxins,
Cover Article: Targeted Toxins in Pain Read More »
Moshnikova A, Frye J, Shay JW, Minna JD, Khokhlatchev AV (2006) The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway. J Biol Chem 281(12):8143-8152. doi: 10.1074/jbc.M511837200 PMID: 16421102 Related Products: Antibody to NORE1A (10F10-C6-C6) (Cat. #AB-V56)
Nolan BC, Freeman JH (2006) Purkinje cell loss by OX7-saporin impairs acquisition and extinction of eyeblink conditioning. Learn Mem 13(3):359-365. doi: 10.1101/lm.168506 Summary: Adaptive adjustments to movements depend on cerebellar learning. This work examines the effect of a global depletion of Purkinje cells in the cerebellar cortex on delay eyeblink conditioning in rats. 15 µg
Frielingsdorf H, Thal LJ, Pizzo DP (2006) The septohippocampal cholinergic system and spatial working memory in the Morris water maze. Behav Brain Res 168(1):37-46. doi: 10.1016/j.bbr.2005.10.008 Summary: The authors examined whether an optimized Morris water maze test could reveal the role of the septohippocampal cholinergic system in spatial working memory. Rats were treated with bilateral
Parikh V, Sarter M (2006) Cortical choline transporter function measured in vivo using choline-sensitive microelectrodes: clearance of endogenous and exogenous choline and effects of removal of cholinergic terminals. J Neurochem 97(2):488-503. doi: 10.1111/j.1471-4159.2006.03766.x Summary: A major projection of brain attention systems passes through the cholinergic portion of the cortical mantle. The authors investigated the role
Weyergang A, Selbo PK, Berg K (2006) Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF-saporin. J Control Release 111(1-2):165-173. doi: 10.1016/j.jconrel.2005.12.002 Summary: In this study the authors investigated the use of photosensitizers located in endocytic vesicles that can be induced to release macromolecules upon activation by light. This process is called photochemical
DiLillo DJ, Pawluczkowycz AW, Peng W, Kennedy AD, Beum PV, Lindorfer MA, Taylor RP (2006) Selective and efficient inhibition of the alternative pathway of complement by a mAb that recognizes C3b/iC3b. Mol Immunol 43(7):1010-1019. doi: 10.1016/j.molimm.2005.05.003 PMID: 15961157 Related Products: Antibody to Complement C3 (1H8) (Cat. #AB-V83)
Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL (2006) Safety evaluation of Intrathecal Substance P-Saporin, a targeted neurotoxin, in dogs. Toxicol Sci 91(1):286-298. doi: 10.1093/toxsci/kfj143 Summary: SP-SAP (Cat. #IT-07) has been shown to reverse neuropathic pain behavior in rodents and prevent
Safety evaluation of Intrathecal Substance P-Saporin, a targeted neurotoxin, in dogs. Read More »