Author name: Kristen Hartman

Kanai T, Uraushihara K, Totsuka T, Nemoto Y, Fujii R, Kawamura T, Makita S, Sawada D, Yagita H, Okumura K, Watanabe M (2006) Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis. J Gastroenterol Hepatol 21(7):1136-1142. doi: 10.1111/j.1440-1746.2006.04391.x Summary: Crohn’s disease is characterized by massive infiltration of macrophages and CD4(+) T-cells […]

Basbaum AI, Julius D (2006) Toward better pain control. Sci Am 294(6):60-67. doi: 10.1038/scientificamerican0606-60 Summary: The authors discuss some of the advances in understanding and treating different types of pain, and specifically outline circuits, receptors, and ligands involved in pain pathways. Several treatments are described, one of which is the use of SP-SAP (Cat. #IT-07)

Vera-Portocarrero LP, Yie JX, Kowal J, Ossipov MH, King T, Porreca F (2006) Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology 130(7):2155-2164. doi: 10.1053/j.gastro.2006.03.025 Summary: Here the authors investigated the role of ascending or descending pathways in the mediation of pain caused by pancreatitis. Rats received 1.5

Grimaldi P, Rossi F (2006) Lack of neurogenesis in the adult rat cerebellum after Purkinje cell degeneration and growth factor infusion. Eur J Neurosci 23(10):2657-2668. doi: 10.1111/j.1460-9568.2006.04803.x Summary: Although neurogenesis occurs in very specific areas of the mammalian brain, neural progenitors can be found in many central nervous system sites. Here the authors examined neurogenesis

Lu J, Sherman D, Devor M, Saper CB (2006) A putative flip-flop switch for control of REM sleep. Nature 441(1):589-594. doi: 10.1038/nature04767 Summary: The authors propose a REM sleep regulatory system that involves GABAergic and glutaminergic neurons in the mesopontine tegmentum. Among other work, 2 µl of 0.1% orexin-SAP (Cat. #IT-20) was injected into the

Dinh TT, Flynn FW, Ritter S (2006) Hypotensive hypovolemia and hypoglycemia activate different hindbrain catecholamine neurons with projections to the hypothalamus. Am J Physiol Regul Integr Comp Physiol 291(4):R870-R879. doi: 10.1152/ajpregu.00094.2006 Summary: Hypovolemia, a decrease in blood plasma volume, results in secretion of arginine vasopressin (AVP). This work investigates the role of hindbrain catecholamine neurons

Madden CJ, Stocker SD, Sved AF (2006) Attenuation of homeostatic responses to hypotension and glucoprivation after destruction of catecholaminergic rostral ventrolateral medulla (RVLM) neurons. Am J Physiol Regul Integr Comp Physiol 291(3):R751-R759. doi: 10.1152/ajpregu.00800.2005 Summary: C1 neurons in the RVLM express dopamine-beta-hydroxylase (DBH). Anti-DBH-SAP (Cat. #IT-03) was used to eliminate these neurons and examine cardiovascular