Kristen Hartman – Page 25 – Advanced Targeting Systems

Urokinase-type plasminogen activator receptor (uPAR) as a therapeutic target in cancer

Zhai BT, Tian H, Sun J, Zou JB, Zhang XF, Cheng JX, Shi YJ, Fan Y, Guo DY (2022) Urokinase-type plasminogen activator receptor (uPAR) as a therapeutic target in cancer. J Translational Medicine 20:135. doi: 10.1186/s12967-022-03329-3 PMID: 35303878 Summary: The authors describe how a conjugate of Saporin and ATF (Urokinase-type plasminogen activator receptor (uPAR) as […]

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A CD45-targeted antibody-drug conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation in mice

Kristen Hartman

Saha A, Hyzy S, Lamothe T, Hammond K, Clark N, Lanieri L, Bhattarai P, Palchaudhuri R, Gillard GO, Proctor J, Riddle MJ, Panoskaltsis-Mortari A, MacMillan ML, Wagner JE, Kiem HP, Olson LM, Blazar BR (2022) A CD45-targeted antibody-drug conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation in mice. Blood 139(11):1743-1759. doi: 10.1182/blood.2021012366 PMID: 34986233

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Immunological barriers to haematopoietic stem cell gene therapy

Kristen Hartman

Charlesworth CT, Hsu I, Wilkinson AC, Nakauchi H (2022) Immunological barriers to haematopoietic stem cell gene therapy. Nat Rev Immunol 1-15. doi: 10.1038/s41577-022-00698-0 Objective: This review article attempts to encourage more research to address the immunological barriers to haematopoietic stem cell based gene therapies. Summary: The authors lay out the history and clinical trials of

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ZAP Internalization Kit Concentrations

Kristen Hartman

Q: We have your ZAP internalization kit and I have a question regarding the concentrations used in the cytotoxicity assay. The Hum-ZAP used in the assay (mentioned in the PDF protocol) is 4.5 nM and the target agent was 10 nM to 1 fM. Is there a stoichiometric relation between Hum-ZAP and the target agent

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Noradrenergic innervations of the medial prefrontal cortex mediate empathy for pain in rats via the α1 and β receptors.

Kristen Hartman

Yun-Fei L, Zhang J, Wang XQ, Peng JJ, Ling BF, Liu FT, Yang F, Dong G, Yu YQ (2022) Noradrenergic innervations of the medial prefrontal cortex mediate empathy for pain in rats via the α1 and β receptors. Behav Brain Res 10:113828. doi: 10.1016/j.bbr.2022.113828 Objective: To study the roles of the locus coeruleus (LC) to

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Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration

Kristen Hartman

Pereira PM, Papy-Garcia D, Barritault D, Chiappini F, Jackisch R, Schimchowitsch S, Cassel JC (2022) Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration. Glycoconj J 39(1):107-130. doi: 10.1007/s10719-022-10047-x PMID: 35254602 Objective: Assess the effects of OTR4132, a synthetic heparan-mimetic biopolymer that is designed to have

Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration Read More »

Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation.

Kristen Hartman

Liu G, Chen Y, Wang Y, Deng X, Xiao Q, Zhang L, Xu H, Han X, Lei A, He J, Li X, Cao Y, Zhou P, He C, Wu P, Jiang W, Tan M, Chen C, Yang Q, Lu L, Deng K, Yao Z, Zhou J (2022) Angiotensin II enhances group 2 innate lymphoid cell

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Local renin angiotensin system and sperm DNA fragmentation

Kristen Hartman

Aparicio Prieto MV, Rodríguez Gallego MV, Valdivia Palacín A, Franco Iriarte Y, Hervás Barbara G, Echevarría Orella E, Casis Saenz L (2022) Local renin angiotensin system and sperm DNA fragmentation. Asian J Androl 24(2):139-146. doi: 10.4103/aja202150 PMID: 34494558 Objective: The renin angiotensin system (RAS) appears to influence male fertility at multiple levels. The relationship between

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Maintenance mechanism of nociplastic pain in males

Kristen Hartman

McDonough KE (2022) Maintenance mechanism of nociplastic pain in males. University of Texas Medical Branch Thesis. Objective: The objective of this dissertation is to elucidate the sex-specific mechanisms underlying the transition to and maintenance of a nociplastic pain state using animal models. Summary: This PhD dissertation investigates the mechanisms underlying the transition from acute to

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Serotonin-1A receptor activation in the median raphe nucleus improves response learning-based strategy in 192IgG saporin-induced cognitive impairments.

Kristen Hartman

Ramezani F, Salehian S, Hosseinzadeh S, Mahjour Z, Babajani T, Ghorbanian D, Feizi F, Pourbagher R (2022) Serotonin-1A receptor activation in the median raphe nucleus improves response learning-based strategy in 192IgG saporin-induced cognitive impairments. Eur J Pharmacol 918:174774. doi: 10.1016/j.ejphar.2022.174774 PMID: 35077674 Objective: Study the effects of median raphe nucleus serotonin-1A autoreceptors stimulation on rats.

Serotonin-1A receptor activation in the median raphe nucleus improves response learning-based strategy in 192IgG saporin-induced cognitive impairments. Read More »

Author name: Kristen Hartman