Author name: Kristen Hartman

A brief history of saporin and its contributions to neuroscience

Shramm PA, Ancheta LR, Bouajram R, Lappi DA (2021) A brief history of saporin and its contributions to neuroscience. Neuroscience 2021 Abstracts J002.11. Society for Neuroscience, Virtual. Summary: When investigating the origins of targeted toxins (a drug, therapy, or scientific tool directed to a unique extracellular target), an appropriate place to begin is with the […]

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Toxic substance-induced hippocampal neurodegeneration in rodents as model of Alzheimer’s dementia

Nurmasitoh T, Sari DCR, Susilowati R (2021) Toxic substance-induced hippocampal neurodegeneration in rodents as model of Alzheimer’s dementia. Open Access Maced J Med Sci [Internet] 9(F):523. Summary: In this review, the authors discussed hippocampal neurodegeneration rodent animal models of Alzheimer’s Dementia and their induction via a toxic substance. Between 2016-2021, 80 studies were reported with

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Light-controlled elimination of PD-L1+ cells

Wong JJW, Selbo PK (2021) Light-controlled elimination of PD-L1+ cells. J Photochem Photobiol B 225:112355. doi: 10.1016/j.jphotobiol.2021.112355 Objective: To investigate novel strategies that simultaneously target both tumor cells and immunosuppressive cells in the tumor microenvironment. The focus was on the evaluation in vitro of Anti-PD-L1-SAP combined with photochemical internalization (PCI) as a therapeutic strategy to

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Violet light modulates the central nervous system to regulate memory and mood

Sasaki N, Gusain P, Hayano M, Sugaya T, Tonegawa N, Hatanaka Y, Tamura R, Okuyama K, Osada H, Ban N, Mitsukura Y, Lang RA, Mimura M, Tsubota K (2021) Violet light modulates the central nervous system to regulate memory and mood. bioRxiv 2021.11.02.466604. doi: 10.1101/2021.11.02.466604 Related Products: Melanopsin Rabbit Polyclonal, affinity-purified (Cat. #AB-N39)

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Hydrophobicity-tuned anion responsiveness underlies endosomolytic cargo delivery mediated by amphipathic vehicle peptides.

Chen X, Liu H, Li A, Ji S, Fei H (2021) Hydrophobicity-tuned anion responsiveness underlies endosomolytic cargo delivery mediated by amphipathic vehicle peptides. J Biol Chem 297(6):101364. doi: 10.1016/j.jbc.2021.101364 Objective: The study focuses on hydrophobicity and a structure-function strategy to evolve a template peptide for endosomolytic cargo delivery. Summary: The peptide LP6 could dramatically promote

Hydrophobicity-tuned anion responsiveness underlies endosomolytic cargo delivery mediated by amphipathic vehicle peptides. Read More »

Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders

Sałaciak K, Pytka K (2022) Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders. Neurosci Biobehav Rev 132:1114-1136. doi: 10.1016/j.neubiorev.2021.10.037 Objective: This review focuses on the sigma-1 receptor as a target for treatment of depression and cognitive disorders. Summary: Sigma-1 receptor ligands, and predominantly agonists, might be the next generation

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Characterizing SERCA function in murine skeletal muscles after 35-37 days of spaceflight

Braun JL, Geromella MS, Hamstra SI, Messner HN, Fajardo VA (2021) Characterizing SERCA function in murine skeletal muscles after 35-37 days of spaceflight. Int J Mol Sci 22(21):11764. doi: 10.3390/ijms222111764 PMID: 34769190 Objective: To investigate SERCA function, SERCA regulatory protein content, and reactive oxygen/nitrogen species (RONS) protein adduction in murine skeletal muscle after 35–37 days

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Probing transferrin receptor overexpression in gastric cancer mice models

Lodhi MS, Khan MT, Bukhari SMH, Sabir SH, Samra ZQ, Butt H, Akram MS (2021) Probing transferrin receptor overexpression in gastric cancer mice models. ACS Omega 6(44):29893-29904. doi: 10.1021/acsomega.1c04382 PMID: 34778662 Objective: To investigate the role of the transferrin receptor, a glycoprotein receptor that is expressed many-folds on rapidly growing cells due to the greater

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Tart cherry extract and omega fatty acids reduce behavioral deficits, gliosis, and amyloid-beta deposition in the 5xFAD mouse model of Alzheimer’s disease

Bowers Z, Maiti P, Bourcier A, Morse J, Jenrow K, Rossignol J, Dunbar GL (2021) Tart cherry extract and omega fatty acids reduce behavioral deficits, gliosis, and amyloid-beta deposition in the 5xFAD mouse model of Alzheimer’s disease. Brain Sci 11(11):1423. doi: 10.3390/brainsci11111423 PMID: 34827424 Objective: To assess the efficacy of Total Body Rhythm (TBR) for

Tart cherry extract and omega fatty acids reduce behavioral deficits, gliosis, and amyloid-beta deposition in the 5xFAD mouse model of Alzheimer’s disease Read More »

Naturally occurring ribosome inactivating proteins might be key molecules against Covid-19

Arslan I, Aydin O, Birdal P (2021) Naturally occurring ribosome inactivating proteins might be key molecules against Covid-19. 2021 5th International Symposium on Multidisciplinary Studies and Innovative Technologies (ISMSIT) 624-627. Ankara, Turkey. doi: 10.1109/ISMSIT52890.2021.9604711 Summary: The authors cover a variety of topics related to the use of Saporin as a potential molecule to study for

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