Ramezani F, Salehian S, Hosseinzadeh S, Mahjour Z, Babajani T, Ghorbanian D, Feizi F, Pourbagher R (2022) Serotonin-1A receptor activation in the median raphe nucleus improves response learning-based strategy in 192IgG saporin-induced cognitive impairments. Eur J Pharmacol 918:174774. doi: 10.1016/j.ejphar.2022.174774 PMID: 35077674
Objective: Investigating the role of Serotonin-1A receptors in spatial navigation.
Summary: 192-IgG-SAP was used to selectively eliminate cholinergic neurons in the brain as a model for deficits found in Alzheimer’s Disease. The spatial navigation skills of the rats treated with 192-IgG-SAP were compared against those that were treated with Saporin in conjunction with another serotonin-1A antagonist or auto receptor stimulant to find the role of serotonin in the median raphe nucleus in movement.
Usage: Selective cholinergic denervation was achieved by intracerebroventricular administration of 192-IgG-SAP (IT-01, 1.0 μl/each ventricle at the rate of 0.2 μl/min ) on male Wistar rats.
Related Products: 192-IgG-SAP (Cat. #IT-01)