Charlesworth CT, Hsu I, Wilkinson AC, Nakauchi H (2022) Immunological barriers to haematopoietic stem cell gene therapy. Nat Rev Immunol 1-15. doi: 10.1038/s41577-022-00698-0
Objective: This review article attempts to encourage more research to address the immunological barriers to haematopoietic stem cell based gene therapies.
Summary: The authors lay out the history and clinical trials of hematopoietic stem cell gene therapy and then discuss the challenges of both innate immunity and adaptive immunity.
Usage: This review mentions a publication that used Anti-CD117-SAP to ablate hematopoietic stem cells.
Related Products: Anti-CD117-SAP (Cat. #IT-83)