Author name: Kristen Hartman

Cover Article: Nucleus tractus solitarii injections of substance P-conjugated saporin selectively disrupts baroflex-dependent pathways.

Contributed by Jeffrey T. Potts, Ph.D., Department of Biomedical Science, College of Veterinary Medicine, Dalton Cardiovascular Research Center, Columbia, MO 65211 The nucleus tractus solitarii (NTS) receives afferent input from visceral, somatic and cardiopulmonary structures and is the first central site for the processing of these sensory autonomic signals. Modulation of sensory neurotransmission has been well […]

Cover Article: Nucleus tractus solitarii injections of substance P-conjugated saporin selectively disrupts baroflex-dependent pathways. Read More »

D1-like dopamine receptors selectively block P/Q-type calcium channels to reduce glutamate release onto cholinergic basal forebrain neurones of immature rats.

Momiyama T, Fukazawa Y (2007) D1-like dopamine receptors selectively block P/Q-type calcium channels to reduce glutamate release onto cholinergic basal forebrain neurones of immature rats. J Physiol 580(Pt 1):103-117. doi: 10.1113/jphysiol.2006.125724 PMID: 17234695 Related Products: 192-IgG Mouse Monoclonal, Cy3-labeled (Cat. #AB-N43FL3)

D1-like dopamine receptors selectively block P/Q-type calcium channels to reduce glutamate release onto cholinergic basal forebrain neurones of immature rats. Read More »

Targeted deletion of neurokinin-1 receptor expressing nucleus tractus solitarii neurons precludes somatosensory depression of arterial baroreceptor-heart rate reflex.

Potts JT, Fong AY, Anguelov PI, Lee S, McGovern D, Grias I (2007) Targeted deletion of neurokinin-1 receptor expressing nucleus tractus solitarii neurons precludes somatosensory depression of arterial baroreceptor-heart rate reflex. Neuroscience 145(3):1168-1181. doi: 10.1016/j.neuroscience.2007.01.001 Summary: Previous work by these authors examined the role of substance P in arterial baroreflex. Here, 1.5 ng bilateral injections

Targeted deletion of neurokinin-1 receptor expressing nucleus tractus solitarii neurons precludes somatosensory depression of arterial baroreceptor-heart rate reflex. Read More »

Astrocytic reaction to a lesion, under hormonal deprivation.

Martinez L, de Lacalle S (2007) Astrocytic reaction to a lesion, under hormonal deprivation. Neurosci Lett 415(2):190-193. doi: 10.1016/j.neulet.2007.01.020 Summary: One effect of estradiol on astrocytes is the mediation of neuronal sprouting. Astrocytes express glial fibrillary acidic protein (GFAP) in response to injury, but estradiol has been shown to repress GFAP expression. Ovariectomized female rats

Astrocytic reaction to a lesion, under hormonal deprivation. Read More »

Decreased vesicular acetylcholine transporter and alpha(4)beta(2) nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning.

Quinlivan M, Chalon S, Vergote J, Henderson J, Katsifis A, Kassiou M, Guilloteau D (2007) Decreased vesicular acetylcholine transporter and alpha(4)beta(2) nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning. Neurosci Lett 415(2):97-101. doi: 10.1016/j.neulet.2006.08.065 Summary: The vesicular acetylcholine transporter (VAChT) is a useful imaging target to assess Alzheimer’s disease, since this transporter

Decreased vesicular acetylcholine transporter and alpha(4)beta(2) nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning. Read More »

Olfactory neophobia and seizure susceptibility phenotypes in an animal model of epilepsy are normalized by impairment of brain corticotropin releasing factor.

Pascual J, Heinrichs SC (2007) Olfactory neophobia and seizure susceptibility phenotypes in an animal model of epilepsy are normalized by impairment of brain corticotropin releasing factor. Epilepsia 48:827-833. doi: 10.1111/j.1528-1167.2007.01024.x Summary: Olfactory recognition has been linked to epilepsy in behavioral phenotype models. This work examines the role brain stress neuropeptides play in the manifestation of

Olfactory neophobia and seizure susceptibility phenotypes in an animal model of epilepsy are normalized by impairment of brain corticotropin releasing factor. Read More »

Immunotoxic cholinergic lesions in the basal forebrain reverse the effects of entorhinal cortex lesions on conditioned odor aversion in the rat.

Ferry B, Herbeaux K, Cosquer B, Traissard N, Galani R, Cassel JC (2007) Immunotoxic cholinergic lesions in the basal forebrain reverse the effects of entorhinal cortex lesions on conditioned odor aversion in the rat. Neurobiol Learn Mem 88:114-126. doi: 10.1016/j.nlm.2007.01.007 Summary: The entorhinal cortex (EC) is intimately involved in olfactory learning. Lesioning of this structure

Immunotoxic cholinergic lesions in the basal forebrain reverse the effects of entorhinal cortex lesions on conditioned odor aversion in the rat. Read More »

Lesions to the nucleus basalis magnocellularis lower performance but do not block the retention of a previously acquired learning set.

Bailey AM, Lee JM (2007) Lesions to the nucleus basalis magnocellularis lower performance but do not block the retention of a previously acquired learning set. Brain Res 1136:110-121. doi: 10.1016/j.brainres.2006.12.028 Summary: A major source of cholinergic innervation to several cortices is the nucleus basalis magnocellularis (NBM). Rats were trained to acquire an olfactory discrimination learning

Lesions to the nucleus basalis magnocellularis lower performance but do not block the retention of a previously acquired learning set. Read More »

Effect of the destruction of cells containing the serotonin reuptake transporter on urethrogenital reflexes.

Gravitt K, Marson L (2007) Effect of the destruction of cells containing the serotonin reuptake transporter on urethrogenital reflexes. J Sex Med 4:322-331. doi: 10.1111/j.1743-6109.2007.00436.x Summary: Using the fact that the urethrogenital (UG) reflex is an autonomic and somatic response, the authors developed a model for ejaculatory-like reflexes. Anti-SERT-SAP (Cat. #IT-23) was bilaterally injected into

Effect of the destruction of cells containing the serotonin reuptake transporter on urethrogenital reflexes. Read More »

Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury.

Zhao P, Waxman SG, Hains BC (2007) Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. J Neurosci 27:2357-2368. doi: 10.1523/JNEUROSCI.0138-07.2007 PMID: 17329433 Summary: Spinal cord injury frequently leads to the development of long-term chronic pain. Recent data has shown that activated microglia are involved in the maintenance of

Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. Read More »

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