Author name: Kristen Hartman

Anticonvulsant effects of damage to structures involved in seizure induction in rats exposed to soman.

Myhrer T, Enger S, Aas P (2007) Anticonvulsant effects of damage to structures involved in seizure induction in rats exposed to soman. Neurotoxicology 28(4):819-828. doi: 10.1016/j.neuro.2007.03.010 Summary: Soman is a nerve agent that irreversibly inhibits acetylcholinesterase, resulting in respiratory dysfunction, seizures, convulsions, coma, and death. In this work the authors investigated whether elimination of cholinergic […]

Anticonvulsant effects of damage to structures involved in seizure induction in rats exposed to soman. Read More »

Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy.

Gibbs RB, Johnson DA (2007) Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy. Neurobiol Learn Mem 88:19-32. doi: 10.1016/j.nlm.2007.03.007 Summary: It has been well established that the cholinergic system of the basal forebrain plays a critical role in many cognitive processes. This work

Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy. Read More »

Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin.

Hess PR, Barnes C, Woolard MD, Johnson MD, Cullen JM, Collins EJ, Frelinger JA (2007) Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin. Blood 109:3300-3307. doi: 10.1182/blood-2006-06-028001 Objective: To discover if pathogenic T cells could be selectively deleted. Summary: A single injection of

Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin. Read More »

Extensive training in a maze task reduces neurogenesis in the adult rat dentate gyrus probably as a result of stress.

Aztiria E, Capodieci G, Arancio L, Leanza G (2007) Extensive training in a maze task reduces neurogenesis in the adult rat dentate gyrus probably as a result of stress. Neurosci Lett 416(2):133-137. doi: 10.1016/j.neulet.2007.01.069 Summary: Ascending cholinergic inputs from the basal forebrain modulate hippocampal neurogenesis, although it is not clear if the modulation is direct

Extensive training in a maze task reduces neurogenesis in the adult rat dentate gyrus probably as a result of stress. Read More »

Targeting Tools: Goat-ZAP

Goat-ZAP (Cat. #IT-36) is a new secondary conjugate of affinity-purified rabbit anti-goat IgG and the ribosome-inactivating protein, saporin. This product uses affinity-purified rabbit anti-goat IgG to “piggyback” onto YOUR primary goat antibody in order to evaluate the ability of your primary antibody to internalize. Once the conjugate is internalized, saporin breaks away from the targeting

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Targeting Tools: Fluorescent Conjugates

ATS has added three new products to our fluorescent conjugates line. Alexa488-labeled affinity purified NGFr* (Cat. #AB-N01APFLA) FITC-labeled Goat Anti-Rat IgG (Cat. #FL-10) FITC-labeled Donkey Anti-Goat IgG (Cat. #FL-11) *(Cat. #AB-N01AP) These conjugates are excellent tools to verify specific binding to an antigen. By first incubating cells with the primary antibody, and then binding the

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Agonist Effects

Q: Do conjugated toxins (dermorphin-saporin in particular) exhibit agonist effects? I’ve generated behavioral and tissue time course effects but have not established agonist effects for this conjugated toxin. A: The peptide ligand toxins should exhibit agonist effects. They are constructed purposely to retain complete agonist activity, including for us the most important: internalization. So, for

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Featured Article: Nucleus tractus solitarii injections of substance P-conjugated saporin selectively disrupts baroflex-dependent pathways

Potts JT (2007) Featured Article: Nucleus tractus solitarii injections of substance P-conjugated saporin selectively disrupts baroflex-dependent pathways. Targeting Trends 8(2) Related Products: SP-SAP (Cat. #IT-07) Read the featured article in Targeting Trends. See Also: Potts JT et al. Targeted deletion of neurokinin-1 receptor expressing nucleus tractus solitarii neurons precludes somatosensory depression of arterial baroreceptor-heart rate

Featured Article: Nucleus tractus solitarii injections of substance P-conjugated saporin selectively disrupts baroflex-dependent pathways Read More »

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