Author name: Kristen Hartman

Role of layer 6 of V2 visual cortex in object-recognition memory.

Lopez-Aranda MF, Lopez-Tellez JF, Navarro-Lobato I, Masmudi-Martin M, Gutierrez A, Khan ZU (2009) Role of layer 6 of V2 visual cortex in object-recognition memory. Science 325:87-89. doi: 10.1126/science.1170869 Summary: The authors examined the role of the V2 visual cortex in visual memory. Working with the prediction that object-recognition memory (ORM) control is centered in the […]

Role of layer 6 of V2 visual cortex in object-recognition memory. Read More »

Targeting Article: SBIR Grant Funded: Selective Activation in Neuronal Populations

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ATS has been awarded a Phase I SBIR grant to develop a new line of products. Dr. Douglas Lappi is the Principal Investigator and Brian Russell is the Lead Scientist on the project. Molecules targeted towards cell surface markers have been used for years to identify specific cell types. It has been demonstrated over the

Targeting Article: SBIR Grant Funded: Selective Activation in Neuronal Populations Read More »

Cover Article: Depletion of Microglia by Mac-1-SAP in Mouse Hippocampal Slice Cultures Enhances Ischemia-Like Neurodegeneration

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Contributed by Maria Montero (a), Berta Gonzalez (b), Jens Zimmer (a)(a) Anatomy and Neurobiology, University of Southern Denmark, Denmark(b) Histology Unit, Autonomous University of Barcelona, Spain Microglial cells contribute about 12% of the cells in the brain, acting as “biosensors” for homeostatic regulation in normal and pathological conditions.[3,13] Resting microglial cells in the adult brain

Cover Article: Depletion of Microglia by Mac-1-SAP in Mouse Hippocampal Slice Cultures Enhances Ischemia-Like Neurodegeneration Read More »

A cholinergic-dependent role for the entorhinal cortex in trace fear conditioning.

Esclassan F, Coutureau E, Di Scala G, Marchand AR (2009) A cholinergic-dependent role for the entorhinal cortex in trace fear conditioning. J Neurosci 29:8087-8093. doi: 10.1523/JNEUROSCI.0543-09.2009 Summary: Higher cognitive involvement can be modeled through the use of trace conditioning in simple associative tasks. Rats received several 20-80 ng injections of 192-IgG-SAP (Cat. #IT-01) into the

A cholinergic-dependent role for the entorhinal cortex in trace fear conditioning. Read More »

Evaluation of side effects through selective ablation of the mu opioid receptor expressing descending nociceptive facilitatory neurons in the rostral ventromedial medulla with dermorphin-saporin.

Cao F, Chen SS, Yan XF, Xiao XP, Liu XJ, Yang SB, Xu AJ, Gao F, Yang H, Chen ZJ, Tian YK (2009) Evaluation of side effects through selective ablation of the mu opioid receptor expressing descending nociceptive facilitatory neurons in the rostral ventromedial medulla with dermorphin-saporin. Neurotoxicology 30(6):1096-1106. doi: 10.1016/j.neuro.2009.06.004 Summary: Selective ablation of

Evaluation of side effects through selective ablation of the mu opioid receptor expressing descending nociceptive facilitatory neurons in the rostral ventromedial medulla with dermorphin-saporin. Read More »

Neuropeptide Y receptor-expressing dorsal horn neurons: role in nocifensive reflex responses to heat and formalin.

Wiley RG, Lemons LL, Kline IV RH (2009) Neuropeptide Y receptor-expressing dorsal horn neurons: role in nocifensive reflex responses to heat and formalin. Neuroscience 161:139-147. doi: 10.1016/j.neuroscience.2008.12.017 Summary: This work examines the effect of lumbar intrathecal administration of NPY-SAP (Cat. #IT-28), and the role of Y1 NPY receptor-expressing neurons (Y1R) in response to thermal and

Neuropeptide Y receptor-expressing dorsal horn neurons: role in nocifensive reflex responses to heat and formalin. Read More »

Neonatal stress affects vulnerability of cholinergic neurons and cognition in the rat: Involvement of the HPA axis.

Aisa B, Gil-Bea FJ, Marcos B, Tordera R, Lasheras B, Del Rio J, Ramirez MJ (2009) Neonatal stress affects vulnerability of cholinergic neurons and cognition in the rat: Involvement of the HPA axis. Psychoneuroendocrinology 34(10):1495-1505. doi: 10.1016/j.psyneuen.2009.05.003 Summary: Early adverse life events such as maternal separation (MS) can increase vulnerability to psychopathology as an adult.

Neonatal stress affects vulnerability of cholinergic neurons and cognition in the rat: Involvement of the HPA axis. Read More »

Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting.

Ray AP, Chebolu S, Ramirez J, Darmani NA (2009) Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting. Behav Neurosci 123:701-706. doi: 10.1037/a0015733 Summary: In this work the authors investigated the role of central and peripheral nervous systems components that mediate the emetic reflex. Least shrews received an 600-ng injection of SSP-SAP (Cat.

Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting. Read More »

Effect of voluntary running on adult hippocampal neurogenesis in cholinergic lesioned mice.

Ho NF, Han SP, Dawe GS (2009) Effect of voluntary running on adult hippocampal neurogenesis in cholinergic lesioned mice. BMC Neurosci 10:57. doi: 10.1186/1471-2202-10-57 Summary: The act of running can induce hippocampal neurogenesis. In this work the authors investigated whether running can offset the loss of septohippocamal cholinergic neurons caused by a lesion using mu

Effect of voluntary running on adult hippocampal neurogenesis in cholinergic lesioned mice. Read More »

A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response.

Radley JJ, Gosselink KL, Sawchenko PE (2009) A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response. J Neurosci 29:7330-7340. doi: 10.1523/JNEUROSCI.5924-08.2009 Summary: GABAergic neurons have been implicated in the negative regulation of the hypothalamic-pituitary-adrenal axis (HPA). In order to clarify GABAergic input to the paraventricular hypothalamic nucleus the authors injected

A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response. Read More »

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