Author name: Kristen Hartman

Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain.

Rivat C, Vera-Portocarrero LP, Ibrahim MM, Mata HP, Stagg NJ, De Felice M, Porreca F, Malan TP (2009) Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain. Eur J Neurosci 29:727-737. doi: 10.1111/j.1460-9568.2009.06616.x Summary: Opioids activate hyperalgesia and allodynia. The authors test the hypothesis that NK-1 […]

Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain. Read More »

Developmental forebrain cholinergic lesion and environmental enrichment: behaviour, CA1 cytoarchitecture and neurogenesis.

Frechette M, Rennie K, Pappas BA (2009) Developmental forebrain cholinergic lesion and environmental enrichment: behaviour, CA1 cytoarchitecture and neurogenesis. Brain Res 1252:172-182. doi: 10.1016/j.brainres.2008.11.082 Summary: The authors investigated the effect of neonatal cholinergic lesions on plasticity in the presence or absence of enrichment. Each lateral ventricle of 7 day-old rats received 300 ng of 192-IgG-SAP

Developmental forebrain cholinergic lesion and environmental enrichment: behaviour, CA1 cytoarchitecture and neurogenesis. Read More »

Neuroprotective effects of testosterone on the morphology and function of somatic motoneurons following the death of neighboring motoneurons.

Little CM, Coons KD, Sengelaub DR (2009) Neuroprotective effects of testosterone on the morphology and function of somatic motoneurons following the death of neighboring motoneurons. J Comp Neurol 512:359-372. doi: 10.1002/cne.21885 Summary: Atrophy of androgen-sensitive motoneurons due to proximity to damaged motoneurons can be attenuated by testosterone. This work examined whether typical motoneurons respond in

Neuroprotective effects of testosterone on the morphology and function of somatic motoneurons following the death of neighboring motoneurons. Read More »

Effects of the selective lesions of cholinergic septohippocampal neurons on different forms of memory and learning process.

Dashniani MG, Beseliia GV, Maglakelidze GA, Burdzhanadze MA, Chkhikvishvili N (2009) Effects of the selective lesions of cholinergic septohippocampal neurons on different forms of memory and learning process. Georgian Med News 166:81-85. Summary: The hippocampus is crucial for the ability to recollect everyday events and factual knowledge. Here the authors looked at the role of

Effects of the selective lesions of cholinergic septohippocampal neurons on different forms of memory and learning process. Read More »

Featured Article: Selective deletion of CD8+ T cells by saporin-coupled MHC class I tetramers

Hess PR, Buntzman AS, Murray SL, Young EF, Frelinger JA (2009) Featured Article: Selective deletion of CD8+ T cells by saporin-coupled MHC class I tetramers. Targeting Trends 10(1) Related Products: Streptavidin-ZAP (Cat. #IT-27), Saporin Goat Polyclonal, affinity-purified FITC-labeled (Cat. #AB-15APFL) Read the featured article in Targeting Trends. See Also: Hess PR et al. Selective deletion

Featured Article: Selective deletion of CD8+ T cells by saporin-coupled MHC class I tetramers Read More »

Cover Article: Selective deletion of CD8+ T cells by saporin-coupled MHC class I tetramers

News Article /

Contributed by Paul R. Hess, Adam S. Buntzman, Sabrina L. Murray, Ellen F. Young, and Jeffrey A. Frelinger;North Carolina State University College of Veterinary Medicine, Raleigh, NC;and University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC CD8+ T cells constitute important effectors of the adaptive immune response, functioning principally to remove infected cells

Cover Article: Selective deletion of CD8+ T cells by saporin-coupled MHC class I tetramers Read More »

Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts

Anderberg C, Li H, Fredriksson L, Andrae J, Betsholtz C, Li X, Eriksson U, Pietras K (2009) Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts. Cancer Res 69(1):369-378. doi: 10.1158/0008-5472.CAN-08-2724 PMID: 19118022 Usage: Receptor stimulation and immunoprecipitation.  B16/mock, B16/PDGF-C, and porcine aortic endothelial cells stably expressing PDGFR-a (a-PAE) were

Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts Read More »

Sex differences in micro-opioid receptor expression in the rat midbrain periaqueductal gray are essential for eliciting sex differences in morphine analgesia.

Loyd DR, Wang X, Murphy AZ (2008) Sex differences in micro-opioid receptor expression in the rat midbrain periaqueductal gray are essential for eliciting sex differences in morphine analgesia. J Neurosci 28:14007-14017. doi: 10.1523/JNEUROSCI.4123-08.2008 Summary: The authors test whether the periaqueductal gray (PAG), that contains a dense population of µ-opioid receptor (MOR)-expressing neurons, is sexually dimorphic.

Sex differences in micro-opioid receptor expression in the rat midbrain periaqueductal gray are essential for eliciting sex differences in morphine analgesia. Read More »

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