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Effect of voluntary running on adult hippocampal neurogenesis in cholinergic lesioned mice.

Ho NF, Han SP, Dawe GS (2009) Effect of voluntary running on adult hippocampal neurogenesis in cholinergic lesioned mice. BMC Neurosci 10:57. doi: 10.1186/1471-2202-10-57

Summary: The act of running can induce hippocampal neurogenesis. In this work the authors investigated whether running can offset the loss of septohippocamal cholinergic neurons caused by a lesion using mu p75-SAP (Cat. #IT-16). Mice received 3.6 µg of the toxin into each lateral ventricle. Although the number of surviving neurons was similar in both lesioned and control animals, most of the progenitor cells in the lesioned animals could not survive without cholinergic input.

Related Products: mu p75-SAP (Cat. #IT-16)