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History of Saporin

The deletion of glucagon-like peptide-1 receptors expressing neurons in the dorsomedial hypothalamic nucleus disrupts the diurnal feeding pattern and induces hyperphagia and obesity

Maejima Y, Yokota S, Shimizu M, Horita S, Kobayashi D, Hazama A, Shimomura K (2021) The deletion of glucagon-like peptide-1...

Saporin from Saponaria officinalis as a tool for experimental research, modeling, and therapy in neuroscience.

Bolshakov AP, Stepanichev MY, Dobryakova YV, Spivak, YS, Markevich, VA (2020) Saporin from Saponaria officinalis as a tool for experimental...

Quantum dot conjugated saporin activates microglia and induces selective substantia nigra degeneration.

Landrigan J, Dwyer Z, Beauchamp S, Rodriguez R, Fortin T, Hayley S (2020) Quantum dot conjugated saporin activates microglia and...

Astroglia in Alzheimer’s Disease.

Verkhratsky A, Parpura V, Rodriguez-Arellano J, Zorec R (2019) Astroglia in Alzheimer’s Disease. Verkhratsky A, Ho M, Zorec R, Parpura...

Strategies to improve the clinical utility of saporin-based targeted toxins

Giansanti F, Flavell DJ, Angelucci F, Fabbrini MS, Ippoliti R (2018) Strategies to improve the clinical utility of saporin-based targeted...

Validation and characterization of a novel method for selective vagal deafferentation of the gut.

Diepenbroek C, Quinn D, Stephens R, Zollinger B, Anderson S, Pan A, de Lartigue G (2017) Validation and characterization of...

KNDy neurons modulate the magnitude of the steroid-induced luteinizing hormone surges in ovariectomized rats.

Helena C, Toporikova N, Kalil B, Stathopoulos A, Pogrebna V, Carolino R, Anselmo-Franci J, Bertram R (2015) KNDy neurons modulate...

GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain.

Keimpema E, Zheng K, Barde SS, Berghuis P, Dobszay MB, Schnell R, Mulder J, Luiten PG, Xu ZD, Runesson J,...

Ribosome-inactivating proteins in cancer treatment

Lappi DA, Stirpe F (2014) Ribosome-inactivating proteins in cancer treatment. (eds. F. Stirpe, D.A. Lappi): In: Ribosome-inactivating Proteins 244-252. doi:...

IB4(+) and TRPV1(+) sensory neurons mediate pain but not proliferation in a mouse model of squamous cell carcinoma.

Ye Y, Bae S, Viet CT, Troob S, Bernabe D, Schmidt BL (2014) IB4(+) and TRPV1(+) sensory neurons mediate pain...

Experimental glomerular endothelial injury in vivo.

Haddad G, Zhu LF, Rayner DC, Murray AG ( 2013 ) Experimental glomerular endothelial injury in vivo. PLoS One 8(10):e78244...

The cells and circuitry for itch responses in mice.

Mishra SK, Hoon MA (2013) The cells and circuitry for itch responses in mice. Science 340(6135):968-971. doi: 10.1126/science.1233765 Mishra SK,...

A nociceptive signaling role for neuromedin B.

Mishra SK, Holzman S, Hoon MA (2012) A nociceptive signaling role for neuromedin B. J Neurosci 32(25):8686-8695. doi: 10.1523/JNEUROSCI.1533-12.2012 Mishra...

Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms.

Li AJ, Wiater MF, Oostrom MT, Smith BR, Wang Q, Dinh TT, Roberts BL, Jansen HT, Ritter S (2012) Leptin-sensitive...

Cracking down on inhibition: Selective removal of GABAergic interneurons from hippocampal networks.

Antonucci F, Alpar A, Kacza J, Caleo M, Verderio C, Giani A, Martens H, Chaudhry FA, Allegra M, Grosche J,...

Immunotoxins and other conjugates containing saporin-s6 for cancer therapy.

Polito L, Bortolotti M, Pedrazzi M, Bolognesi A (2011) Immunotoxins and other conjugates containing saporin-s6 for cancer therapy. Toxins (Basel)...

Cholinergic depletion in the nucleus accumbens: Effects on amphetamine response and sensorimotor gating.

Laplante F, Lappi DA, Sullivan RM (2011) Cholinergic depletion in the nucleus accumbens: Effects on amphetamine response and sensorimotor gating....

A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain.

Baskin DG, Kim F, Gelling RW, Russell BJ, Schwartz MW, Morton GJ, Simhan HN, Moralejo DH, Blevins JE (2010) A...

The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo

Lyu MA, Rai D, Ahn KS, Sung B, Cheung LH, Marks JW, Aggarwal BB, Aguiar RC, Gandhi V, Rosenblum MG...

Cellular basis of itch sensation.

Sun YG, Zhao ZQ, Meng XL, Yin J, Liu XY, Chen ZF (2009) Cellular basis of itch sensation. Science 325:1531-1534....