Author name: Kristen Hartman

Substance P neurotransmission and violent aggression: the role of tachykinin NK(1) receptors in the hypothalamic attack area.

Halasz J, Zelena D, Toth M, Tulogdi A, Mikics E, Haller J (2009) Substance P neurotransmission and violent aggression: the role of tachykinin NK(1) receptors in the hypothalamic attack area. Eur J Pharmacol 611:35-43. doi: 10.1016/j.ejphar.2009.03.050 Summary: Stimulation of the hypothalamic attack area elicits biting attacks in rats. The authors eliminated NK1 receptor-expressing neurons in […]

Substance P neurotransmission and violent aggression: the role of tachykinin NK(1) receptors in the hypothalamic attack area. Read More »

Effects of chronic donepezil treatment and cholinergic deafferentation on parietal pyramidal neuron morphology.

De Bartolo P, Gelfo F, Mandolesi L, Foti F, Cutuli D, Petrosini L (2009) Effects of chronic donepezil treatment and cholinergic deafferentation on parietal pyramidal neuron morphology. J Alzheimers Dis 17:177-191. doi: 10.3233/JAD-2009-1035 PMID: 19494441 Summary: Donepezil has been shown to enhance cognitive functioning in both healthy patients and those suffering from dementia. This study

Effects of chronic donepezil treatment and cholinergic deafferentation on parietal pyramidal neuron morphology. Read More »

Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection.

Browning PG, Gaffan D, Croxson PL, Baxter MG (2010) Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection. Cereb Cortex 20(2):282-293. doi: 10.1093/cercor/bhp097 Summary: In this work the authors investigated the link between connections carried by the fornix and cholinergic input to the inferotemporal cortex in

Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection. Read More »

Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats.

Abbott SB, Stornetta RL, Fortuna MG, Depuy SD, West GH, Harris TE, Guyenet PG (2009) Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats. J Neurosci 29:5806-5819. doi: 10.1523/JNEUROSCI.1106-09.2009 Summary: The retrotrapezoid nucleus (RTN) contains a subpopulation of cells that are thought to function as central respiratory chemoreceptors. The

Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats. Read More »

The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity.

Ramanathan D, Tuszynski MH, Conner JM (2009) The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity. J Neurosci 29:5992-6000. doi: 10.1523/JNEUROSCI.0230-09.2009 Summary: In this work the authors examined what types of neuronal plasticity require the cholinergic system. Selective depletion of the basal forebrain cholinergic system was accomplished by bilateral 112-ng

The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity. Read More »

Anxiety-like behavior is modulated by a discrete subpopulation of interneurons in the basolateral amygdala.

Truitt WA, Johnson PL, Dietrich AD, Fitz SD, Shekhar A (2009) Anxiety-like behavior is modulated by a discrete subpopulation of interneurons in the basolateral amygdala. Neuroscience 160:284-294. doi: 10.1016/j.neuroscience.2009.01.083 Summary: It is thought that the basolateral nucleus of the amygdala (BL) is an anxiety regulator. The authors previously demonstrated that SSP-SAP (Cat. #IT-11) lesions of

Anxiety-like behavior is modulated by a discrete subpopulation of interneurons in the basolateral amygdala. Read More »

Noradrenergic neurons in the locus coeruleus contribute to neuropathic pain.

Brightwell JJ, Taylor BK (2009) Noradrenergic neurons in the locus coeruleus contribute to neuropathic pain. Neuroscience 160:174-185. doi: 10.1016/j.neuroscience.2009.02.023 Summary: Noradrenergic neurons were eliminated with 5 µg intracerebroventricular injections of anti-DBH-SAP (Cat. #IT-03). Mouse IgG-SAP (Cat. #IT-18) was used as a control. Animals lesioned with anti-DBH-SAP displayed a reduction in behavioral signs of several kinds

Noradrenergic neurons in the locus coeruleus contribute to neuropathic pain. Read More »

Targeting Tools: CTB-SAP

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CTB-SAP (Cat. #IT-14) is a conjugate between the cell-binding component of cholera toxin (the B chain) and saporin. CTB binds to GM1 (monosialotetrahexosylganglioside), which is present on the surface of different neurons. It has been suggested to be involved in many problems (besides the most famous in the gut: cholera) of neuronal systems: Parkinson’s, motor

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Targeting Tools: Hug-M-ZAP

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This secondary conjugate (molecular weight 210 kDa) recognizes YOUR human monoclonal IgM antibody. Hug-M-ZAP (IT-43) is a chemical conjugate of affinity-purified goat anti-human IgM and the ribosome-inactivating protein, saporin. Hug-M- ZAP uses your primary human monoclonal IgM antibody to target and eliminate cells and can be used to evaluate the potential of a primary antibody

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Cholinergic depletion of the medial septum followed by phase shifting does not impair memory or rest-activity rhythms measured under standard light/dark conditions in rats.

Craig LA, Hong NS, Kopp J, McDonald RJ (2009) Cholinergic depletion of the medial septum followed by phase shifting does not impair memory or rest-activity rhythms measured under standard light/dark conditions in rats. Brain Res Bull 79(1):53-62. doi: 10.1016/j.brainresbull.2008.10.013 Summary: It has been theorized that cognitive decline observed in Alzheimer’s disease is in part due

Cholinergic depletion of the medial septum followed by phase shifting does not impair memory or rest-activity rhythms measured under standard light/dark conditions in rats. Read More »

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