Esclassan F, Coutureau E, Di Scala G, Marchand AR (2009) A cholinergic-dependent role for the entorhinal cortex in trace fear conditioning. J Neurosci 29:8087-8093. doi: 10.1523/JNEUROSCI.0543-09.2009
Summary: Higher cognitive involvement can be modeled through the use of trace conditioning in simple associative tasks. Rats received several 20-80 ng injections of 192-IgG-SAP (Cat. #IT-01) into the entorhinal cortex (EC) in order to clarify the mechanisms that allow learning through the association of events that occur at different times. Cholinergic depletion of the EC did not result in a training deficit, indicating that these cells are not necessary for trace conditioning.
Related Products: 192-IgG-SAP (Cat. #IT-01)