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  4. A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response.

A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response.

Radley JJ, Gosselink KL, Sawchenko PE (2009) A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response. J Neurosci 29:7330-7340. doi: 10.1523/JNEUROSCI.5924-08.2009

Summary: GABAergic neurons have been implicated in the negative regulation of the hypothalamic-pituitary-adrenal axis (HPA). In order to clarify GABAergic input to the paraventricular hypothalamic nucleus the authors injected 0.23 µg of GAT1-SAP (Cat. #IT-32) into the anterior bed nucleus of the stria terminalis. Both unilateral and bilateral injections were used. Rabbit IgG-SAP (Cat. #IT-35) was used as a control. The data indicate that the GABAergic neuronal population functions as proximate mediator of HPA-inhibitory limbic influences.

Related Products: GAT1-SAP (Cat. #IT-32), Rabbit IgG-SAP (Cat. #IT-35)

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