Author name: Kristen Hartman

Distinct neural pathways mediate alpha7 nicotinic acetylcholine receptor-dependent activation of the forebrain.

Thomsen MS, Hay-Schmidt A, Hansen HH, Mikkelsen JD (2010) Distinct neural pathways mediate alpha7 nicotinic acetylcholine receptor-dependent activation of the forebrain. Cereb Cortex 20(9):2092-2102. doi: 10.1093/cercor/bhp283 Summary: a7 nicotinic acetylcholine receptor (nAChR) agonists are potential treatments for some aspect of schizophrenia. The authors examine whether cholinergic neurons in the horizontal limb of the diagonal band […]

Distinct neural pathways mediate alpha7 nicotinic acetylcholine receptor-dependent activation of the forebrain. Read More »

Cover Article: Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats

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Contributed by Ai-Jun Li, Qing Wang, Thu T. Dinh and Sue Ritter Programs in Neuroscience, Washington State University, Pullman, Washington 99164-6520, USA Leptin is a fat tissue-derived hormone with widespread actions in brain and peripheral tissues. Leptin’s actions are mediated by the long isoform of the leptin receptor, OB-Rb, which has a lengthy intracellular region

Cover Article: Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats Read More »

Estrogen therapy and cognition: a review of the cholinergic hypothesis.

Gibbs RB (2010) Estrogen therapy and cognition: a review of the cholinergic hypothesis. Endocr Rev 31(2):224-253. doi: 10.1210/er.2009-0036 Summary: This review discusses estrogen therapy for use in postmenopausal women. In this context the issues revolve around benefits vs. harm of such therapy on the brain and cognitive impairment associated with aging and Alzheimer’s disease. Use

Estrogen therapy and cognition: a review of the cholinergic hypothesis. Read More »

Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum.

Robertson RT, Baratta J, Yu J, LaFerla FM (2009) Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience 164:1334-1346. doi: 10.1016/j.neuroscience.2009.09.024 Summary: In this work the authors developed a model to examine the relationship between afferent projections and the formation of amyloid-beta (Aβ) deposits. Mice received

Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Read More »

Serotonin transport and metabolism in the mammary gland modulates secretory activation and involution.

Marshall AM, Nommsen-Rivers LA, Hernandez LL, Dewey KG, Chantry CJ, Gregerson KA, Horseman ND (2010) Serotonin transport and metabolism in the mammary gland modulates secretory activation and involution. J Clin Endocrinol Metab 95(2):837-846. doi: 10.1210/jc.2009-1575 PMID: 19965920 Summary: Serotonin is known to be a local regulator of lactation homeostasis. This work examined  the roles of

Serotonin transport and metabolism in the mammary gland modulates secretory activation and involution. Read More »

Neuroprotective effects of testosterone on dendritic morphology following partial motoneuron depletion: efficacy in female rats.

Wilson RE, Coons KD, Sengelaub DR (2009) Neuroprotective effects of testosterone on dendritic morphology following partial motoneuron depletion: efficacy in female rats. Neurosci Lett 465:123-127. doi: 10.1016/j.neulet.2009.09.007 Summary: Previous work has demonstrated a protective effect from testosterone in a motoneuron nerve injury model for male rats. This work investigated whether testosterone has the same effect

Neuroprotective effects of testosterone on dendritic morphology following partial motoneuron depletion: efficacy in female rats. Read More »

Attenuated CCK-induced satiation and increased weight gain following destruction of abdominal vagal afferents by intravagal OX7-saporin conjugate.

Bukowski RK, Duffy TE, Ryu V, Covasa M, Czaja K, Ritter RC (2009) Attenuated CCK-induced satiation and increased weight gain following destruction of abdominal vagal afferents by intravagal OX7-saporin conjugate. Neuroscience 2009 Abstracts 870.5/DD2. Society for Neuroscience, Chicago, IL. Summary: Bilateral subdiaphragmatic vagotomy attenuates reduction of food intake by cholecystokinin (CCK) and other GI satiation

Attenuated CCK-induced satiation and increased weight gain following destruction of abdominal vagal afferents by intravagal OX7-saporin conjugate. Read More »

Using visual search to examine cholinergic contributions to feature binding in the rat.

Botly LC, De Rosa E (2009) Using visual search to examine cholinergic contributions to feature binding in the rat. Neuroscience 2009 Abstracts 873.26/EE13. Society for Neuroscience, Chicago, IL. Summary: According to the feature integration theory of attention, feature binding is an attention-dependent process whereby the different features of an object are simultaneously integrated to form

Using visual search to examine cholinergic contributions to feature binding in the rat. Read More »

Effect of aging and prefrontal cholinergic deafferentation on working memory for familiar and novel odors.

Carter ES, Newman LA, Mcgaughy J (2009) Effect of aging and prefrontal cholinergic deafferentation on working memory for familiar and novel odors. Neuroscience 2009 Abstracts 879.14/EE124. Society for Neuroscience, Chicago, IL. Summary: Aging is associated with cholinergic fiber loss in the entorhinal cortex (EC). Previous research has shown that acetylcholine (ACh) in this region mediates

Effect of aging and prefrontal cholinergic deafferentation on working memory for familiar and novel odors. Read More »

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