Robertson RT, Baratta J, Yu J, LaFerla FM (2009) Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience 164:1334-1346. doi: 10.1016/j.neuroscience.2009.09.024
Summary: In this work the authors developed a model to examine the relationship between afferent projections and the formation of amyloid-beta (Aβ) deposits. Mice received 1.86 µg unilateral injections of 192-IgG-SAP (Cat. #IT-01) into the lateral ventricle. Lesioned animals had persistent Aβ immunoreactivity in layer III of the granular division of retrosplenial cortex (RSg). This data indicates that septal cholinergic axonal projections transport Aβ or amyloid precursor protein to layer III of the RSg.
Related Products: 192-IgG-SAP (Cat. #IT-01), mu p75-SAP (Cat. #IT-16)