Question: I was wondering if you could elaborate on why the Streptavidin-ZAP product recommends to be used at an equimolar ratio with the targeting reagent, when it is capable of binding up to four biotins/molecule? Answer: It’s a question we get asked sometimes and it’s a good question. You are correct that streptavidin is capable […]
Equimolar mixing of Streptavidin-ZAP and Biotinylated Molecule Read More »
Q: I read on your website that, “There are two types of RIPs: type I, which are much less cytotoxic due to the lack of the B chain and type II, which are distinguished from type I RIPs by the presence of the B chain and their ability to enter cells on their own.” In
Which type of RIP is saporin? Read More »
Sonokawa T, Obi N, Usuda J, Sudo Y, Hamakubo T (2023) Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate. Thorac Cancer 14(7):645-653. doi: 10.1111/1759-7714.14776 PMID: 36655546 Objective: Using a photo-sensitizer and red light to release Cetuximab-saporin to target cancer. Summary: Photodynamic therapy is a non-invasive cancer treatment using a photo-sensitizer
Summary: These results indicate a prominent role of NA-neurons vs. ACh ones in impairments of working memory, relevant for Alzheimer’s Disease. Usage: Bilateral icv injection of 192-IgG-SAP and/or Anti-DBH-SAP. G. Leanza and R. Zorec. Function 2023, 4(1) DOI: 10.1093/function/zqac060. We would be pleased to send you our 2023 ATS calendar. Click here to provide us your
Saporin Publication highlighting 192-IgG-SAP and Anti-DBH-SAP Read More »
Iqbal Z, Lei Z, Ramkrishnan AS, Liu S, Hasan M, Akter M, Lam YY, Li Y (2023) Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats. Commun Biol 6:10. doi: 10.1038/s42003-022-04405-6 PMID: 36604595 Objective: To identify the role of norepinephrine in colorectal distention (sub-threshold for acute pain) induced conditioned
Leanza G, Zorec R (2023) Towards astroglia-based noradrenergic hypothesis of Alzheimer’s disease. Function (Oxf) 4(1):zqac060., IT. doi: 10.1093/function/zqac060 PMID: 36590326 Summary: These results indicate a prominent role of NA-neurons vs. ACh neurons in impairments of working memory, relevant for AD, and are consistent with an astrocyte-specific metabolic impairment in a mouse model of intellectual disability.
Towards astroglia-based noradrenergic hypothesis of Alzheimer’s disease Read More »
Fullerton E (2022) The impact of advanced age on morphine anti-hyperalgesia and the role of mu opioid receptor signaling in the periaqueductal gray of male and female rats. Georgia State University Thesis. doi: 10.57709/30509896 Objective: To investigate the impact of advanced age on the antihyperalgesic effect of morphine, as well as its association with changes
Maunze B (2022) Pituitary adenylate cylase-activating polypeptide receptor: Multiple signaling pathways involved in energy homeostasis. Marquette University Dissertations 1212. Thesis. Objective: To determine the endogenous role of pituitary adenylate cyclase activating polypeptide (PACAP) in affecting the ventromedial nuclei (VMN) of the hypothalamus and its control of feeding and energy expenditure through the Type I PAC1
Liu H, Xue Y, Chen L (2022) Angiotensin II increases the firing activity of pallidal neurons and participates in motor control in rats. Metab Brain Dis 38:573-587. doi: 10.1007/s11011-022-01127-w PMID: 36454502 Objective: To investigate the functions of angiotensin II (Ang II)/angiotensin subtype 1 receptor (AT1R) on the globus pallidus neurons of both normal and Parkinsonian
Yamamoto-Fukuda T, Akiyama N, Tatsumi N, Okabe M, Kojima H (2022) Keratinocyte growth factor stimulates growth of p75+ neural crest lineage cells during middle ear cholesteatoma formation in mice. Am J Pathol 192(11):1573-1591. doi: 10.1016/j.ajpath.2022.07.010 PMID: 36210210 Objective: To identify the role of neural crest (NC) lineage epithelial cells during cholesteatoma formation and to detect