Author name: Kristen Hartman

Diminished norepinephrine release in the BSTv decreases anxiety but does not promote maternal behavior in nulliparous female rats.

Holschbach MA, Lonstein JS (2011) Diminished norepinephrine release in the BSTv decreases anxiety but does not promote maternal behavior in nulliparous female rats. Neuroscience 2011 Abstracts 86.06. Society for Neuroscience, Washington, DC. Summary: Postpartum caregiving heavily depends on both increased motivation to interact with offspring and decreased emotional reactivity. The early postpartum period is associated […]

Diminished norepinephrine release in the BSTv decreases anxiety but does not promote maternal behavior in nulliparous female rats. Read More »

Basal metabolic substrate utilization is altered by lesion of hindbrain catecholamine neurons that innervate the medial hypothalamus and substrate selection during glucoprivation is impaired.

Ritter S, Li A-J, Wang Q, Dinh TT (2011) Basal metabolic substrate utilization is altered by lesion of hindbrain catecholamine neurons that innervate the medial hypothalamus and substrate selection during glucoprivation is impaired. Neuroscience 2011 Abstracts 88.05. Society for Neuroscience, Washington, DC. Summary: Central injection of the targeted immunotoxin, anti-dopamine beta hydroxylase (DBH)-saporin (DSAP), retrogradely

Basal metabolic substrate utilization is altered by lesion of hindbrain catecholamine neurons that innervate the medial hypothalamus and substrate selection during glucoprivation is impaired. Read More »

Impaired social interaction and enhanced sensitivity to phencyclidine-induced deficits in novel object recognition in rats with cortical cholinergic denervation.

Savage S, Kehr J, Olson L, Mattsson A (2011) Impaired social interaction and enhanced sensitivity to phencyclidine-induced deficits in novel object recognition in rats with cortical cholinergic denervation. Neuroscience 195:60-69. doi: 10.1016/j.neuroscience.2011.08.027 Summary: Forebrain cholinergic dysfunction is thought to be part of the pathophysiology of schizophrenia. The authors lesioned the cholinergic corticopetal projection of rats

Impaired social interaction and enhanced sensitivity to phencyclidine-induced deficits in novel object recognition in rats with cortical cholinergic denervation. Read More »

Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats.

Abbott SB, Stornetta RL, Coates MB, Guyenet PG (2011) Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats. J Neurosci 31(45):16410-16422. doi: 10.1523/JNEUROSCI.3280-11.2011 Summary: Neurons in the retrotrapezoid nucleus (RTN) are involved in the CO2-dependent control of breathing in conscious and anesthetized rats. In this work the authors specifically

Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats. Read More »

Cholinergic modulation of a specific memory function of prefrontal cortex.

Croxson PL, Kyriazis DA, Baxter MG (2011) Cholinergic modulation of a specific memory function of prefrontal cortex. Nat Neurosci 14(12):1510-1512. doi: 10.1038/nn.2971 Summary: The authors investigated loss of acetylcholine in the large and highly differentiated PFC’s of rhesus monkeys. The monkeys received 80-92 20-ng injections of ME20.4-SAP (Cat. #IT-15) per hemisphere. Lesioned animals were severely

Cholinergic modulation of a specific memory function of prefrontal cortex. Read More »

Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.

Liu XY, Liu ZC, Sun YG, Ross M, Kim S, Tsai FF, Li QF, Jeffry J, Kim JY, Loh HH, Chen ZF (2011) Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids. Cell 147(2):447-458. doi: 10.1016/j.cell.2011.08.043 Summary: Recent work has begun to define the different pathways used by itch and pain.

Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids. Read More »

Featured Article: Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity

King T, Porreca F (2011) Featured Article: Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity. Targeting Trends 12(4) Related Products: SSP-SAP (Cat. #IT-11), Blank-SAP (Cat. #IT-21) Read the featured article in Targeting Trends. See Also: King T et al. Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity.

Featured Article: Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity Read More »

Cover Article: Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity

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Contributed by Tamara King and Frank Porreca Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA A common symptom of patients with neuropathic pain is spontaneous pain, often described as burning. Some patients also suffer from pain elicited by normally non-noxious stimuli, such as touch, referred to as allodynia. Preclinical studies have

Cover Article: Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity Read More »

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