Targeted conjugates are widely used to escort payloads to specific cell populations in vitro and in vivo for both basic research and pharmaceutical development. Desirable traits of a Targeting Agent include high specificity and rapid internalization. The Targeting Agent can be an antibody, peptide, protein, or any other molecule that recognizes a cell- surface marker. […]
Targeting Tools: ZAP Biotin-Z Internalization Kit Read More »
ATS is pleased to announce Beta-release of a wide array of targeted toxins for use in eliminating specific cell types. This Beta-Testing Program will make new conjugates available to our customers sooner. Each of the Beta products will have: Saporin activity confirmed, Peptide sequences published/confirmed, and/or Antibody binding specificity published/confirmed. Beta Products have not been
Targeting Tools: Beta Testing Program Read More »
Q: I ordered a control conjugate to use alongside my targeted conjugate, but the two products are at different concentrations. How much control conjugate should I use? A: Conjugate products are often of differing protein concentrations, meaning dilution of one is usually necessary to ensure comparable amounts of control conjugate and targeted conjugate are used.
Conjugate Calculations Read More »
Q: I have been using your ZAP Antibody Internalization Kit. It is working well for me, but I can only test one antibody at a time. Do you offer the ZAP kit in larger sizes? A: We do offer kits with sufficient components to test multiple antibody candidates. We offer “Z4” and “Z10” sizes of
Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, Villano JL (2014) Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarkers Prev 23(10):1985-1996. doi: 10.1158/1055-9965.EPI-14-0275 PMID: 25053711 Objective: The authors report on the current epidemiology of glioblastomas (GBM) with data from the Central Brain Tumor Registry of the United Stated (CBTRUS)
Epidemiologic and molecular prognostic review of glioblastoma Read More »
Dog with bone cancer jumps for joy over new treatment that made him pain-free after one dose! Otis, the golden retriever, was in his golden years when bone cancer pain threatened to shorten his life. As a participant in a clinical trial aimed at pet dogs, he was given a single treatment with a pain
Otis Gets His Wag Back! Read More »
Based on the recent publication by: Brown DC, Agnello K. (2013) Intrathecal substance p-saporin in the dog: efficacy in bone cancer pain. Anesthesiology 119(5):1178-1185 and the October 2013 press release by the American Society of Anesthesiologists, “Man’s best friends’ chronic pain relieved with new treatment, study finds: Findings could be useful to human cancer patients.”
Mao C, Li H, Zhang Z, Kiyama T, Panda S, Hattar S, Ribelayga C, Mills S, Wang S (2014) T-box transcription regulator Tbr2 is essential for the formation and maintenance of Opn4/melanopsin-expressing intrinsically photosensitive retinal ganglion cells. J Neurosci 34:13083-13095. doi: 10.1523/JNEUROSCI.1027-14.2014 PMID: 25253855 Summary: Opsin 4/melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) are responsible
Luo W, Lin B, Wang Y, Zhong J, O’Meally R, Cole R, Pandey A, Levchenko A, Semenza G (2014) PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility. Mol Biol Cell 25:2788-2796. doi: 10.1091/mbc.E14-02-0775 PMID: 25079693 Usage: Western blot Related Products: Trans-4-Hydroxy-L-Proline Rabbit Polyclonal, Conjugated (Cat. #AB-T044)
Zhao Z, Wan L, Liu X, Huo F, Li H, Barry D, Krieger S, Kim S, Liu Z, Xu J, Rogers B, Li Y, Chen Z (2014) Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission. J Neurosci 34:12402-12414. doi: 10.1523/JNEUROSCI.1709-14.2014 Summary: After itch detection, the itch pathway moves through an array of