Author name: Kristen Hartman

Depletion of inflammatory dendritic cells with anti-CD209 conjugated to saporin toxin.

Alonso M, Gregorio J, Davidson M, Gonzalez J, Engleman E (2014) Depletion of inflammatory dendritic cells with anti-CD209 conjugated to saporin toxin. Immunol Res 58:374-377. doi: 10.1007/s12026-014-8511-6 Objective: To investigate a strategy that avoids monocyte intermediates to deplete inflammatory dendritic cells (DCs). Mice with an abundance of inflammatory DCs as a consequence of lipopolysaccharide exposure […]

Depletion of inflammatory dendritic cells with anti-CD209 conjugated to saporin toxin. Read More »

Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions.

Vetrivelan R, Saper C, Fuller P (2014) Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions. Nat Sci Sleep 6:57-63. doi: 10.2147/NSS.S53132 Summary: Excessive daytime sleepiness is often treated with modafinil. Armodafinil, the R-isomer of modafinil, has been introduced for clinical use, but little is known about the cellular pathway targeted by these drugs. The authors

Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions. Read More »

Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress.

Flak J, Myers B, Solomon M, McKlveen J, Krause E, Herman J (2014) Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress. Eur J Neurosci 39:1903-1911. doi: 10.1111/ejn.12587 Summary: Chronic stress can cause dysregulation of the paraventricular nucleus (PVN) of the hypothalamus, resulting in structural and function changes in the neurons involved. There

Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress. Read More »

Role of lateral hypothalamus in two aspects of attention in associative learning.

Wheeler D, Wan S, Miller A, Angeli N, Adileh B, Hu W, Holland P (2014) Role of lateral hypothalamus in two aspects of attention in associative learning. Eur J Neurosci 40:2359-2377. doi: 10.1111/ejn.12592 Summary: The lateral hypothalamic (LH) region contains both orexin and melanin-concentrating hormone (MCH) neurons. These neurons are unique to the LH but

Role of lateral hypothalamus in two aspects of attention in associative learning. Read More »

Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease.

Shin E, Rogers J, Devoto P, Björklund A, Carta M (2014) Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. Exp Neurol 257:25-38. doi: 10.1016/j.expneurol.2014.04.011 Summary: Although Parkinson’s disease is usually associated with loss of dopaminergic neurons in the substantia nigra, post-mortem studies have shown

Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. Read More »

The rate of fall of blood glucose determines the necessity of forebrain-projecting catecholaminergic neurons for male rat sympathoadrenal responses.

Jokiaho A, Donovan C, Watts A (2014) The rate of fall of blood glucose determines the necessity of forebrain-projecting catecholaminergic neurons for male rat sympathoadrenal responses. Diabetes 63:2854-2865. doi: 10.2337/db13-1753 Summary: Different sets of glucosensors detect insulin-induced hypoglycemia depending on the onset rate. This detection controls the activation of sympathoadrenal counterregulatory responses (CRRs). Slow onset

The rate of fall of blood glucose determines the necessity of forebrain-projecting catecholaminergic neurons for male rat sympathoadrenal responses. Read More »

Effects of hypocretin/orexin cell transplantation on narcoleptic-like sleep behavior in rats.

Arias-Carrión O, Murillo-Rodríguez E (2014) Effects of hypocretin/orexin cell transplantation on narcoleptic-like sleep behavior in rats. PLoS One 9:e95342. doi: 10.1371/journal.pone.0095342 Summary: In this work the authors examined the effect of orexin cell grafts into the lateral hypothalamus (LH) on narcoleptic-like sleep behavior. Rats received bilateral 490-ng injections of orexin-SAP* into the LH. 21 days

Effects of hypocretin/orexin cell transplantation on narcoleptic-like sleep behavior in rats. Read More »

Targeting Tools: Top Twenty

Top Five Targeted Toxins #1. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) targets cells expressing rat p75NTR #2. Anti-DBH-SAP (Cat. #IT-03) targets cells expressing rat dopamine beta-hydroxylase (DBH) #3. mu p75-SAP (Cat. #IT-16) targets cells expressing mouse p75NTR #4. IB4-SAP (Cat. #IT-10) targets cells expressing α-D-galactopyranoside residues #5. Mac-1-SAP mouse/human (Cat. #IT-06) targets cells expressing mouse / human

Targeting Tools: Top Twenty Read More »

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