Author name: Kristen Hartman

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.

Zheng X, Zhai B, Koivunen P, Shin S, Lu G, Liu J, Geisen C, Chakraborty A, Moslehi J, Smalley D, Wei X, Chen X, Chen Z, Beres J, Zhang J, Tsao J, Brenner M, Zhang Y, Fan C, DePinho R, Paik J, Gygi S, Kaelin W, Zhang Q (2014) Prolyl hydroxylation by EglN2 destabilizes FOXO3a […]

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Read More »

New mouse retinal stroke model reveals direction-selective circuit damage linked to permanent optokinetic response loss.

Joly S, Guzik-Kornacka A, Schwab M, Pernet V (2014) New mouse retinal stroke model reveals direction-selective circuit damage linked to permanent optokinetic response loss. Invest Ophthalmol Vis Sci 55:4476-4489. doi: 10.1167/iovs.14-14521 PMID: 24970264 Summary: The authors used a mouse model of ‘retinal stroke’ to better delineate the optokinetic response deficits at the cellular level. Damage

New mouse retinal stroke model reveals direction-selective circuit damage linked to permanent optokinetic response loss. Read More »

Descending controls modulate inflammatory joint pain and regulate CXC chemokine and iNOS expression in the dorsal horn.

Carr F, Géranton S, Hunt S (2014) Descending controls modulate inflammatory joint pain and regulate CXC chemokine and iNOS expression in the dorsal horn. Mol Pain 10:39. doi: 10.1186/1744-8069-10-39 Summary: Peripheral joint pathology in conditions such as osteoarthritis does not always correlate to the amount of pain experienced, indicating that chronic pain is present. The

Descending controls modulate inflammatory joint pain and regulate CXC chemokine and iNOS expression in the dorsal horn. Read More »

The cholinergic basal forebrain in the ferret and its inputs to the auditory cortex.

Bajo V, Leach N, Cordery P, Nodal F, King A (2014) The cholinergic basal forebrain in the ferret and its inputs to the auditory cortex. Eur J Neurosci 40:2922-2940. doi: 10.1111/ejn.12653 PMID: 24945075 Summary: The ferret has become a more common animal model in auditory neuroscience. Unlike rodent models, however, anatomical data describing the organization

The cholinergic basal forebrain in the ferret and its inputs to the auditory cortex. Read More »

Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria.

Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I (2014) Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria. Am J Physiol Renal Physiol 306:F1462-1476. doi: 10.1152/ajprenal.00623.2013 PMID: 24761004 Summary: The authors utilized a mouse model

Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria. Read More »

Expression of different neurokinin-1 receptor (NK1R) isoforms in glioblastoma multiforme: potential implications for targeted therapy.

Cordier D, Gerber A, Kluba C, Bauman A, Hutter G, Mindt TL, Mariani L (2014) Expression of different neurokinin-1 receptor (NK1R) isoforms in glioblastoma multiforme: potential implications for targeted therapy. Cancer Biother Radiopharm 29(5):221-226. doi: 10.1089/cbr.2013.1588 Summary: The neurokinin-1 receptor (NK1r) has been found to be consistently over-expressed in gliomas, making it a potential target

Expression of different neurokinin-1 receptor (NK1R) isoforms in glioblastoma multiforme: potential implications for targeted therapy. Read More »

Cholinergic immunotoxin 192 IgG-saporin alters subicular theta-gamma activity and impairs spatial learning in rats.

Rastogi S, Unni S, Sharma S, Laxmi T, Kutty B (2014) Cholinergic immunotoxin 192 IgG-saporin alters subicular theta-gamma activity and impairs spatial learning in rats. Neurobiol Learn Mem 114:117-126. doi: 10.1016/j.nlm.2014.05.008 Summary: The authors investigated the role of the subiculum in spatial informational processing, specifically cholinergic modulation of subicular theta-gamma activity. Rats received 50-ng injections

Cholinergic immunotoxin 192 IgG-saporin alters subicular theta-gamma activity and impairs spatial learning in rats. Read More »

Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release.

Nunan R, Sivasathiaseelan H, Khan D, Zaben M, Gray W (2014) Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release. Glia 62:1313-1327. doi: 10.1002/glia.22682 Summary: Postnatal and adult learning and memory require hippocampal neurogenesis. Cognitive dysfunction is frequently accompanied by neuroinflammatory pathogenesis, but the pathways by which the immune

Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release. Read More »

[Targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-HT and c-Fos in spinal dorsal horn of rats].

Cao J, Wu T, Zhang L (2014) [Targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-HT and c-Fos in spinal dorsal horn of rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi 30:218-222. Summary: Pain threshold, 5-hydroxytryptamine (5-HT) expression, and c-Fos expression were measured in rats after

[Targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-HT and c-Fos in spinal dorsal horn of rats]. Read More »

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